o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 238 and better comparability of the data obtained with in vivo Comet experiments. These aspects include: number of doses tested, number of animals per dose, slides per animal, number of cells, sufficient DNA migration in cells of concurrent controls and minimum time of treatment of slides with alkaline buffer. 18.05.2004 (300) Type : other: Drosophila reversion assay Species : Drosophila melanogaster Sex : male Strain : Route of admin. : other: oral feed of larvae Exposure period : continuous feeding Doses : 10, 25, 50, 100 mM (ca. 1.1, 2.7, 5.4, 10.7 g) Result : negative Method : other: Rasmuson et al. (1978): Mut. Res. 54, 33-38 Year : 1983 GLP : no data Test substance : other TS: no data on purity Test condition : Test system: newly hatched male larvae carrying the unstable white-zeste system and an excision-repair deficient gene mei-9a Reliability : (4) not assignable no validated test system 02.06.2004 (344) (345) Type : other: Inhibition of Testicular DNA-Synthesis Species : mouse Sex : male Strain : no data Route of admin. : oral unspecified Exposure period : Doses : 0, 200 mg/kg b.w. Result : positive Method : other: according to Friedman and Staub, 1976, Mutation Res. 37, 67-76, see also freetext TC Year : 1977 GLP : no data Test substance : other TS:o-toluidine, no data on purity Result : Incorporation of the tritiated thymidine = 75% of concurrent controls Test condition : Measurement of incorporation of [3H]thymidine into testicular DNA (expressed as cpm per µg DNA). The mean values were then tested for statistically significant deviations from the concurrent controls by simplified t-test. Method evaluation Reliability : (4) not assignable Method evaluation 02.06.2004 (346) Type : other: Somatic recombination and mutation (SRM) assay Species : Drosophila melanogaster Sex : male/female Strain : Route of admin. : oral feed Exposure period : 4 days (egg-laying period) Doses : 2.0 - 8.0 mM Result : positive Method : other: Becker, H.J. (1966): Curr. Topics Develop. Biol. 1,155-171 Year : 1985 UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : Using the white-coral somatic eye color system Remark : control: yes, concurrent vehicle Reliability : (4) not assignable no validated test system 02.06.2004 (347) (345) Type : other: Somatic recombination and mutation (SRM) assay Species : Drosophila melanogaster Sex : male/female Strain : no data Route of admin. : oral feed Exposure period : acute and chronic treatment Doses : 5 % solution in ethanol Result : positive Method : other: according Graf et.al., 1983 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : With the excision-proficient standard cross, the acute exposure carried out with relatively high concentrations gave a positive response in one case. The chronic exposures did not yield clear-cut positive results. Test condition : Types of larvae: repair-proficient heterozygous (-/mei-9) and excision-repair-defective (mei-9) Larvae were exposed for: acute feeding - for 2h or 6h at a larval age of 48 or 72h; concentration: 1-5 mg/ml chronic feeding - until pupation beginning at a larval age of 48h (duration of feeding 72h) or 72h (duration of feeding 48h). In some cases, larvae were treated during the entire larval live (96h). concentration: 0.1-0.5 mg/ml Analysis of wings Conclusion : Authors consider that the acute treatment with high concentrations as more conclusive and therefore classify o-toluidine as positive in acute treatments. Reliability : (4) not assignable no validated test method 02.06.2004 (345) (348) Type : other: Somatic recombination and mutation (SRM) assay Species : Drosophila melanogaster Sex : male/female Strain : Route of admin. : other: oral feed of larvae Exposure period : until pupation Doses : 0, 1, 2 mM in Tween 80 plus ethanol or water Result : negative Method : other: based upon the white-ivory system developed Green et al., 1986 Year : 1994 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable no validated test method 02.06.2004 (349) UNEP PUBLICATIONS 239
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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