o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
138
increased diurese - day 1 up to day 14
800 mg/kg: reduced general condition, anaesthesia,
cyanosis, bloody eyes - day 1 up to day 14
900 mg/kg: reduced general condition, anaesthesia,
cyanosis, bloody eyes - day 1 up to time of
death
Test condition : TEST ORGANISMS:
- Animals: Wistar II male rats
- Age: 6 - 7 weeks
- Weight at study initiation: 160 -180 g
ADMINISTRATION:
- Route: gavage
- Doses per time period: single
- Doses: 0.6, 0.65,0.7, 0.8, 0.9 ml/kg bw corresponding to 600 - 650 -
700 - 800 - 900 mg/kg bw
(density: 0.998 g/cm³)
- Vehicle: none
- observation period: 14 days
Reliability : (2) valid with restrictions
no necropsy and no histopathological examinations were performed
Flag : Critical study for SIDS endpoint
13.12.2004 (141)
Type : other
Value : >= 50 mg/kg bw
Species : cat
Strain : no data
Sex : male/female
Number of animals : 2
Vehicle : water
Doses : 50 mg/kg bw
Method : other: see freetext ME
Year : 1977
GLP : no
Test substance : other TS: o-toluidine, no data on purity
Method : Single oral application of 50 mg/kg bw o-toluidine dissolved in water (5%
solution) was given by gavage to 2 cats/sex; observation time: 14 days
Record of signs of intoxication, methemoglobinemia and mortality
Result : Mortality of 1/2 males after 7 days
Signs of intoxications:
lateral position, tachypnea, cyanosis, mydriasis, apathy, salivation,
vomiting (2 cats), refuse of feed, weight loss
2 cats recovered within 4 and 11 days, respectively.
1 cat was in poor condition after 14 days
Methemoglobinemia:
before treatment: no measurable concentrations
4 hours after application of TS:
males: 71.7 %, 71.1 %
females: 69.4 %, 59.6 %
Source : BASF AG
Reliability : (2) valid with restrictions
only 1 dose used, no data on purity of TS
Flag : Critical study for SIDS endpoint
27.05.2004 (142)
Type : LD50
Value : = 900 mg/kg bw
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