o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 240 Type : other: chromosomal aberrations Species : mouse Sex : no data Strain : other: Lacca Route of admin. : other: injection (no further information) Exposure period : 24 hours Doses : 0.01 mmol/kg, 1 mmol/kg bw in ethylalcohol Result : positive Method : other: see freetext ME Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : Ts was injected into mice and chromosome preparations were malde from bone marrow of cholchicimized animals. (no further information) negative control: Ethanol positive control: no data Reliability : (4) not assignable documentation insufficient for assessment 02.06.2004 (350) Type : other: sperm head abnormality Species : mouse Sex : male Strain : other: Lacca Route of admin. : other: injection (no further information) Exposure period : 5 weeks Doses : 0.01 mmol/kg, 0.1 mmol/kg, 1 mmol/kg in ethanol Result : positive Method : other Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable documentation insufficient for assessment 02.06.2004 (350) Type : other: sperm head abnormality Species : mouse Sex : male Strain : other: (CBAxBALB/c)F1 Route of admin. : i.p. Exposure period : 5 days Doses : 0.05, 0.1, 0.25, 0.5 mg/kg b.w. Result : ambiguous Method : other: sperm morphology assay according Wyrobek and Bruce, 1975 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Result : Result questionable: increases of sperm abnormalities of 1.4% at 0.1 ml/kg and 1.7% at 0.25 ml/kg, but no effect at 0.05 ml/kg. The dose of 0.5 ml/kg was lethal. Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. Reliability : (2) valid with restrictions Method-Evaluation 16.09.2003 (152) (351) Type : other: sperm head abnormality Species : mouse Sex : male Strain : other: (CBAxBALB/c)F1 Route of admin. : i.p. Exposure period : 5 days Doses : 0.05, 0.1, 0.2, 0.25, 0.3, 0.4, 0.5 ml/kg b.w. per day in corn oil Result : negative Method : other: sperm morphology assay according to Topham, Mutation Res. 70, 149-155, 1980 Year : 1980 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable documentation insufficient for assessment: survey of 54 compounds 11.02.2004 (352) Type : other: zeste-white (UZ) somatic mutation assay Species : Drosophila melanogaster Sex : male/female Strain : other: Drosophila melanogaster UZ stock Route of admin. : other: oral feed of larvae Exposure period : single administration Doses : 0.5, 1.0, 2.0 mM in Ethanol/Tween 80 Result : positive Method : other: Rasmuson et al. (1984): Eye pigmentation changes in Drosophila melanogaster in "Handbook of Mutagenicity" (Kilbey et al eds), 603-613 Year : 1991 GLP : no data Test substance : other TS: o-toluidine, solved in 5 % ethanol/1 % Tween 80 Reliability : (4) not assignable no validated test method 02.06.2004 (353) 5.7 CARCINOGENICITY Species : rat Sex : male Strain : Fischer 344 Route of admin. : oral feed Exposure period : 26 weeks Frequency of treatm. : continuously Post exposure period : no Doses : 0, 5000 ppm (approximately 375 mg/kg bw/day) Result : positive Control group : yes, concurrent no treatment Method : other: comparative toxicity and cancerogenicity,see also TC Year : 1992 UNEP PUBLICATIONS 241
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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