o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 95-53-4 DATE: 07.01.2005 92 Documentation insufficient for assessment 15.06.2004 (72) Type : aerobic Inoculum : activated sludge, adapted Concentration : 200 mg/l related to COD (Chemical Oxygen Demand) related to Contact time : Degradation : = 97.7 (±) % after 5 day(s) Result : Deg. product : Method : other: batch system (comparable to Zahn-Wellens Test OECD TG 302B) Year : 1976 GLP : no Test substance : other TS: o-Toluidine, purity is not specified Result : Degradation result based on COD removal; degradation rate: 15.1 mg COD/g/h Test condition : - Duration of the test: 120 h - Concentration of the test substance: 200 mg COD/l - Inoculum was adapted for 20 days. Inoculum concentration applied was 100 mg/l dry matter - The tested substance was the sole carbon source - Temperature = 20+/-3°C; pH = 7.2; mineral medium; dark; continuously stirred Reliability : (2) valid with restrictions Study meets generally accepted scientific principles Flag : Critical study for SIDS endpoint 29.01.2004 (73) Type : aerobic Inoculum : activated sludge, industrial Contact time : Degradation : 96 (±) % after 11 day(s) Result : Deg. product : Method : OECD Guide-line 302 B "Inherent biodegradability: Modified Zahn-Wellens Test" Year : 1981 GLP : no Test substance : other TS: o-Toluidine, purity is not specified Method : Initial test substance concentration: 50-400 mg/l DOC Remark : Acclimatization period: 4 days; approx. 14 % of the elimination caused by physical mechanisms Result : 83 % removal during the log phase (6 days) Reliability : (2) valid with restrictions Guideline study without detailed documentation Flag : Critical study for SIDS endpoint 29.01.2004 (74) Type : aerobic Inoculum : activated sludge, industrial, adapted Concentration : 100 mg/l related to Test substance related to Contact time : Degradation : 92 (±) % after 1 day(s) Result : Deg. product : Method : other: Activated sludge degradability test Year : 1988 UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 95-53-4 DATE: 07.01.2005 GLP : no Test substance : other TS: o-Toluidine, purity is not specified Method : - 2.0 l of the sample water were added to 0.5 l of activated sludge and aeration of the mixed liquor was started. - After 23 h aeration and 1 h sedimentation 2.0 l of the supernantant solution were replaced by the sample water. - The fill and draw system was therefore used to acclimatize the sludge to the test water, the water in the container was sampled during aeration at the beginning (0 h) and 24 h later for analysis. - The oxygen uptake and the decreases in TOC and COD after cultivation were measured and the biological degradability calculated. Remark : Acclimatization period: 1 day; Result : Degradation: 92 % related to COD removal, 83 % related to TOC removal Test condition : - The conditions in the aeration container were: MLSS (mixed liquor suspended solids) 2000-3000 mg/l, air flow rate about 150 ml/min, water temperature = 25-30 °C. Concentration of the water samples was between 100 and 200 mg/l in terms of COD or about 100 mg/l in terms of the concentration of the test substance. pH-value was adjusted to neutral; and both nitrogen and phosphorus were added at 1.3 and 28 mg/l respectively. The salt concentration of the water samples was adjusted to a chloride ion concentration of about 5000 mg/l (same level as that of the wastewater entering the Fukashiba plant). Reliability : (2) valid with restrictions Test procedure in accordance with generally accepted scientific standards and described in sufficient detail 29.01.2004 (75) Type : aerobic Inoculum : other bacteria: Rhodococcus rhodochrous (enriched from agricultural soil) Concentration : 400 mg/l related to Test substance related to Contact time : Degradation : = 100 (±) % after 4 day(s) Result : Deg. product : Method : other Year : 1984 GLP : no Test substance : other TS: o-Toluidine, purity is not specified Deg. products : 3-methylcatechol Method : A Gram-positive bacterium (Rhodococcus rhodochrous) with the ability to utilize o-toluidine as sole source of carbon and nitrogen was isolated from soil. Result : In mineral salts medium containing (NH4)2SO4, complete removal of otoluidine (400 mg/l) was achieved after 2 days of incubation. Using a mineral salts medium without (NH4)2SO4, o-toluidine served as sole source of carbon, nitrogen and energy and was completely degraded after 4 days. In resting-cell experiments 3-methylcatechol was identified as primary metabolite, which was found to be further degraded to 2-hydroxy-6oxohepta-2,4-dienoic acid. Test condition : - Enrichment: A flower-pot was filled with 150 g soil and 0.25 g of otoluidine. The probe was kept at 30 °C with regular moistening. When otoluidine was degraded, as tested by thin-layer chromatography (TLC), UNEP PUBLICATIONS 93
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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