o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

More documents

Recommendations

Info

OECD SIDS o-TOLUIDINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 95-53-4 DATE: 07.01.2005 84 Type of measurement : concentration at contaminated site Media : other: tobacco smoke and ambient air Concentration : Method : GC/MS Method : - GC (Hewlett-Packard 5890 series II and MSD 5971A, Superox II column from Bio-Rad) - 13C1-o-toluidine was obtained from Cambridge Isotope Laboratory - Smoking machine with continuous aspiration of 21 ml/s main stream and 138 ml/s side stream - Absorption of cigarette smoke in acidic solution - Washing on Florisil column - Eluate directly injected into GC/MS - Ambient air sampling via a pump: 33 ml/s (DuPont P4000 with automatically adjusted flow), duration 8.33 h - Sample preparation similar to that of cigarette smoke. Result : Both the main stream smoke of cigarettes, (which is inhaled by the smoker) and the side stream smoke of cigarettes (which is also inhaled by the non smoker) contain significant amounts of all toluidine isomers and other aromatic amines. Depending on the brand, the o-toluidine content is 30- 208 ng/cigarette in the main-stream smoke, and 10-100 times more in the side-stream smoke (2-4 µg/cigarette). In air, there are several aromatic amines (tracers of cigarette smoke). There is a strong correlation of o-toluidine levels (ng/m3) in indoor air with the smoking status of the inhabitants: - Outdoors 2.5 - Apartment of a non smoker 5.1 - Office of a non smoker with smokers in contiguous room 6.3 - Office of a non smoker with smokers in contiguous room after overnight ventilation 3.0 - Office with 1 smoker 5.4 - Office with 2 smokers 12.8 - Club room 16.9 - Non-smoking train compartment 6.5 - Hair-dresser saloon 10.4 Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 07.06.2004 (65) Type of measurement : concentration at contaminated site Media : biota Concentration : Method : GC/MS Method : - VOC of human breath was anaylsed by GC/MS - 10 cancer patients with bronchogenic carcinoma - 16 control subjects - All persons were questioned on their food intake during last 24 h prior to test, additionally medication history was compiled Remark : Contamination of former smokers by environmental tobacco smoke should have been taken into account. Result : Lung cancer patients exhaled significantly greater amounts of o-toluidine (median value: ca. 6 ng/20 l lung air) than age-matched controls (median value: ca. 3 ng/20 l lung air). Since o-toluidine was detected in all patients who have not smoked for 3-15 years, it was discussed that o-toluidine might also stem from broiled food due to pyrolysis of amino acids and from vegetables. Reliability : (2) valid with restrictions Basic data given UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 95-53-4 DATE: 07.01.2005 Flag : Critical study for SIDS endpoint 07.06.2004 (66) Type of measurement : concentration at contaminated site Media : biota Concentration : Method : PTR-MS Method : - VOC of human breath was anaylsed by proton-transfer reaction-mass spectrometry (PTR-MS) with a detection limit of a few pptv - 16 cancer patients - 100 volunteers as control - Parallel check of room air Result : Rieder et al. (2001) observed that patients with different tumors exhaled 5 times more of a compound which they tentatively identified as o-toluidine (1.5 +/- 0.8 ppbv) than the age-matched controls (0.24 +/- 0.1 ppbv). Reliability : (3) invalid Documentation insufficient for assessment 20.06.2004 (67) 3.2.2 FIELD STUDIES 3.3.1 TRANSPORT BETWEEN ENVIRONMENTAL COMPARTMENTS 3.3.2 DISTRIBUTION Media : air - biota - sediment(s) - soil - water Method : Calculation according Mackay, Level I Year : 2003 Method : Chemical data used in the calculation: - Temperature (°C) = 25 - Molar mass (g/mol) = 107.16 - Vapour pressure (Pa) = 34.5 - Water solubility (g/l) = 15.0009 - log Kow = 1.40 - Melting point: -24.4/-16.3 °C(*) Phase properties and composition of the compartments: Volumina Density Organic Carbon (m3) (kg/m3) (%) Air: 6.0 E+09 1.185 Water: 7.0 E+06 1000 Soil: 4.5 E+04 1500 2 Sediment: 2.1 E+04 1300 Susp. Sed.: 3.5 E+01 1500 16.7 Aerosol: 1.2 E-01 1500 Aquatic Biota: 7.0 E+00 1000 5 (lipid content) Result : Calculation was performed according to the model described in the first publication of Mackay (1991). Phase properties and composition of the compartments were modified as suggested by the Federal Environmental Agency (UBA, Germany). (*)Both melting point values lead to the same result. Based on the model calculations (Mackay level I, v 2.11) the target compartment of the environmental distribution of o-toluidine is the UNEP PUBLICATIONS 85
Page 1 and 2:
OECD SIDS o-TOLUIDINE FOREWORD INTR
Page 3 and 4:
OECD SIDS o-TOLUIDINE 11. Comments:
Page 5 and 6:
OECD SIDS o-TOLUIDINE and transitio
Page 7 and 8:
OECD SIDS o-TOLUIDINE countries), e
Page 9 and 10:
OECD SIDS o-TOLUIDINE 1.3 Physico-C
Page 11 and 12:
OECD SIDS o-TOLUIDINE methylene-bis
Page 13 and 14:
OECD SIDS o-TOLUIDINE Table 3 Photo
Page 15 and 16:
OECD SIDS o-TOLUIDINE With adapted
Page 17 and 18:
OECD SIDS o-TOLUIDINE Table 8 Geoac
Page 19 and 20:
OECD SIDS o-TOLUIDINE polluted site
Page 21 and 22:
OECD SIDS o-TOLUIDINE depending on
Page 23 and 24:
OECD SIDS o-TOLUIDINE prepared from
Page 25 and 26:
OECD SIDS o-TOLUIDINE 3.1.2 Acute T
Page 27 and 28:
OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
Page 29 and 30:
OECD SIDS o-TOLUIDINE Inhalation Th
Page 31 and 32:
OECD SIDS o-TOLUIDINE males or fema
Page 33 and 34: OECD SIDS o-TOLUIDINE examination y
Page 35 and 36: OECD SIDS o-TOLUIDINE Conclusion Th
Page 37 and 38: OECD SIDS o-TOLUIDINE According to
Page 39 and 40: OECD SIDS o-TOLUIDINE The lowest te
Page 41 and 42: OECD SIDS o-TOLUIDINE 4.2 Terrestri
Page 43 and 44: OECD SIDS o-TOLUIDINE 6 REFERENCES
Page 45 and 46: OECD SIDS o-TOLUIDINE Bringmann G,
Page 47 and 48: OECD SIDS o-TOLUIDINE Hecht SS, El-
Page 49 and 50: OECD SIDS o-TOLUIDINE phase extract
Page 51 and 52: OECD SIDS o-TOLUIDINE Stark M (1892
Page 53 and 54: OECD SIDS o-TOLUIDINE I U C L I D D
Page 55 and 56: OECD SIDS o-TOLUIDINE 1. GENERAL IN
Page 61 and 62: OECD SIDS o-TOLUIDINE 2. PHYSICO-CH
Page 77 and 78: OECD SIDS o-TOLUIDINE 3. ENVIRONMEN
Page 83: OECD SIDS o-TOLUIDINE 3. ENVIRONMEN
Page 105 and 106: OECD SIDS o-TOLUIDINE 4. ECOTOXICIT
Page 129 and 130: OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 135 and 136:
OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
OECD SIDS o-TOLUIDINE 6. REFERENCES
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297:
show all

o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

Create successful ePaper yourself

Delete template?

Save as template?