o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 190 Metabolic activation : with and without Result : ambiguous Method : other Year : 1981 GLP : no data Test substance : other TS: see freetext TC Result : o-toluidine was quite toxic toward the Salmonella typhimurium strains, but not toward E.coli. It demonstrated weak activity against TA1538, but only after metabolic activation. The type of metabolizing system appeared important, and mixed-induced S9 was effective whereas Aroclor-induced S9 was not. Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: two types: Standard S9 mix - liver homogenates from with Aroclor 1254 induced rats Retests were also carried out with liver homogenates from with phenobarbitone and betanaphthoflavone induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (228) Type : other: UMU test System of testing : Salmonella typhimurium TA 1535/psk1002 Test concentration : 1670 µg/ml (highest dose tested) Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: umu gene expression according Oda et al., 1985 Year : 1987 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable dose range not given, s9 preparation not described, no data on purity of TS,detailed results not described 15.07.2004 (229) Type : Bacterial gene mutation assay System of testing : E.coli rec- strains: JC2921, JC9238, JC8471, JC5519, JC7689 Test concentration : up to 1000 µg/ml or up to cytotoxicity Cycotoxic concentr. : no data Metabolic activation : with Result : positive Method : other: Mutagenesis Assay by DNA-repair-Deficient E.coli Strains Year : 1981 GLP : no data Test substance : other TS: see freetext TC UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates as described by Litton. Reliability : (4) not assignable Method-Evaluation, insufficient documentation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (230) Type : Escherichia coli reverse mutation assay System of testing : Escherichia coli WP2 uvrA + WP2 uvrA /pKM101 Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: see freetext ME Year : 1981 GLP : no data Test substance : other TS: see freetext TC Method : Mutation tests were carried out using a preincubation method (30°C, 30 min) (Matsushima et al. 1980; Yahagi et al. 1977) with and without S9 mix (PCB-induced rat liver metabolic activation system). Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with PCB induced male Sprague Dawley rats Reliability : (4) not assignable Method-Evaluation, no data on test concentrations, no data on cytotoxicity, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (231) Type : Bacillus subtilis recombination assay System of testing : Bacillus subtilis H 17 rec+, M 45 rec- Test concentration : 20µl/disk undiluted UNEP PUBLICATIONS 191
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE countries), e
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE methylene-bis
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OECD SIDS o-TOLUIDINE Table 3 Photo
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OECD SIDS o-TOLUIDINE With adapted
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OECD SIDS o-TOLUIDINE prepared from
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OECD SIDS o-TOLUIDINE 3.1.2 Acute T
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OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE Conclusion Th
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OECD SIDS o-TOLUIDINE The lowest te
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OECD SIDS o-TOLUIDINE 4.2 Terrestri
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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