o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 138 increased diurese - day 1 up to day 14 800 mg/kg: reduced general condition, anaesthesia, cyanosis, bloody eyes - day 1 up to day 14 900 mg/kg: reduced general condition, anaesthesia, cyanosis, bloody eyes - day 1 up to time of death Test condition : TEST ORGANISMS: - Animals: Wistar II male rats - Age: 6 - 7 weeks - Weight at study initiation: 160 -180 g ADMINISTRATION: - Route: gavage - Doses per time period: single - Doses: 0.6, 0.65,0.7, 0.8, 0.9 ml/kg bw corresponding to 600 - 650 - 700 - 800 - 900 mg/kg bw (density: 0.998 g/cm³) - Vehicle: none - observation period: 14 days Reliability : (2) valid with restrictions no necropsy and no histopathological examinations were performed Flag : Critical study for SIDS endpoint 13.12.2004 (141) Type : other Value : >= 50 mg/kg bw Species : cat Strain : no data Sex : male/female Number of animals : 2 Vehicle : water Doses : 50 mg/kg bw Method : other: see freetext ME Year : 1977 GLP : no Test substance : other TS: o-toluidine, no data on purity Method : Single oral application of 50 mg/kg bw o-toluidine dissolved in water (5% solution) was given by gavage to 2 cats/sex; observation time: 14 days Record of signs of intoxication, methemoglobinemia and mortality Result : Mortality of 1/2 males after 7 days Signs of intoxications: lateral position, tachypnea, cyanosis, mydriasis, apathy, salivation, vomiting (2 cats), refuse of feed, weight loss 2 cats recovered within 4 and 11 days, respectively. 1 cat was in poor condition after 14 days Methemoglobinemia: before treatment: no measurable concentrations 4 hours after application of TS: males: 71.7 %, 71.1 % females: 69.4 %, 59.6 % Source : BASF AG Reliability : (2) valid with restrictions only 1 dose used, no data on purity of TS Flag : Critical study for SIDS endpoint 27.05.2004 (142) Type : LD50 Value : = 900 mg/kg bw UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Species : rat Strain : Sprague-Dawley Sex : male Number of animals : Vehicle : other: none Doses : 760 mg/kg bw - 1050 mg/kg bw (no further informations) Method : other: see freetext ME Year : 1972 GLP : no Test substance : other TS: o-toluidine, no data on purity Method : Male Sprague-Dawley rats (200-300 g, number not given) were fasted overnight and then incubated with undiluted o-toluidine, observation time 14 days Calculation of LD50-value: Weil (1952), Tables for convenient calculation of median-effective dose (LD50 or ED50) and instructions in their use. Biometrics 8: 249-263 Result : LD 50 = 900 mg/kg body weight 95 % confidence limit: 760 - 1050 mg/kg bw Signs of intoxication (not specified for o-toluidine, several aniline derivates were tested: Severely intoxicated rats were lethargic, cyanotic (bluish coloration of lower limbs and of mouth and nose), and showed enlarged spleens, darkened organs and blood. Reliability : (4) not assignable number of animals not given, several substances were investigated and necropsy results cannot be related to a respective substance, no histopathological examinations were performed 02.06.2004 (142) (143) Type : LD50 Value : = 520 mg/kg bw Species : mouse Strain : Sex : Number of animals : Vehicle : Doses : Method : other: keine Daten Year : GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable Insufficient documentation and/or Secondary literature 02.06.2004 (144) Type : LD50 Value : = 670 mg/kg bw Species : rat Strain : Sex : no data Number of animals : Vehicle : no data Doses : Method : other: no data Year : 1967 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable UNEP PUBLICATIONS 139
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE I U C L I D D
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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