o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 194 cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (238) Type : Gene mutation in Saccharomyces cerevisiae System of testing : Saccharomyces cerevisiae JD 1 Test concentration : up to 2000 µg/ml Cycotoxic concentr. : > 2000 µg/ml in DMSO Metabolic activation : with and without Result : negative Method : other: according Davis et al., 1975, Mutation Res. 29, 301 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : Assays were performed with or without S9 microsomal fraction obtained from a liver homogenate from rats pretreated with Aroclor 1254 and in a yeast assay optimized for cytochrome P-450 levels in the absence of an exogenous activation system. Remark : mitotic gene conversion Result : The addition of o-toluidine at concentrations up to 2000 µg/ml to stationaryphase or log-phase cultures of S.cerevisiae JD1 did not show any consistent increase in the rate of mitotic gene conversion, either with or without the addition of rat liver S9 fraction or in the optimized yeast P-450 assay. Reliability : (4) not assignable no validated test system 15.07.2004 (239) (234) (240) Type : Gene mutation in Saccharomyces cerevisiae System of testing : strain D61-M, D6 Test concentration : up to 5000 µg/ml Cycotoxic concentr. : Metabolic activation : with and without Result : positive Method : other: according Kelly and Parry (1983) Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : o-toluidine is capable of inducing mitotic chromosome aneuploidy in yeast, the lowest positive concentration was 600 µg/ml Test substance : Ten chemicals were tested for there ability to induce mitotic aneuploidy, point mutation and mitotic segration in strains D6 and D61-M Reliability : (4) not assignable no validated test system 15.07.2004 (234) (241) Type : Gene mutation in Saccharomyces cerevisiae System of testing : strain D61.M Test concentration : 0, 0.5, 0.74, 0.99, 1.23, 1.48, 1.72, 1.96 µg/ml UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Cycotoxic concentr. : no data Metabolic activation : without Result : negative Method : other: according Zimmermann (1975) Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : o-toluidine did not induced mitotic segregation and there was no indication of induction of mitotic aneuploidy Reliability : (4) not assignable no validated test system, no data on cytotoxicity 15.07.2004 (234) (242) Type : Gene mutation in Saccharomyces cerevisiae System of testing : strain D7 Test concentration : 2 µl/ml Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: according Zimmermann (1975) Year : 1981 GLP : no data Test substance : other TS: see freetext TC Remark : mitotic gene conversion Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (4) not assignable Method-Evaluation, only one concentration tested, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (243) Type : Gene mutation in Saccharomyces cerevisiae System of testing : Strains D7-144, XV185-14C, RM52 Test concentration : 378, 756, 1512, 3024 µg/ml Cycotoxic concentr. : >=1512 µg/ml (-S9); >= 756 µg/ml (+S9) Metabolic activation : with and without Result : negative Method : other: as described by Mehta and von Borstel (1982) Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Remark : Endpoints: Mitotic gene conversion and reverse mutation Result : o-toulidine was tested positive in mitotic gene conversion in strain RM52 without metabolic activation. Lowest effective concentration was 1512 UNEP PUBLICATIONS 195
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE Table 3 Photo
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OECD SIDS o-TOLUIDINE 3.1.2 Acute T
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OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE Conclusion Th
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OECD SIDS o-TOLUIDINE 4.2 Terrestri
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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