o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
---In the present work the compound with code no 41 is declared as otoluidine
hydrochloride, whereas in an the overall summary of this program
code no. 41 is declared as o-toluidine.
METABOLIC ACTIVATION:
S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar
rats
Reliability : (4) not assignable
Method-Evaluation, documentation insufficient, unclear use: o-toluidine or
o-toluidine hydrochloride
15.07.2004 (152) (198)
Type : Ames test
System of testing : Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
Test concentration : 1000 µg/plate (highest tested concentration)
Cycotoxic concentr. : no data
Metabolic activation : with and without
Result : negative
Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975)
Year : 1979
GLP : no data
Test substance : other TS: o-toluidine, no data on purity
Test condition : METABOLIC ACTIVATION:
S9 mix liver homogenates from Aroclor 1254 induced male Sprague-
Dawley rats
solvent control and positive controls not mentioned.
Reliability : (4) not assignable
concentration range not given, no negative and positive controls reported,
cytotoxic concentration not reported, no data on purity of TS
15.07.2004 (199)
Type : Ames test
System of testing : Salmonella typhimurium TA 98, TA 100
Test concentration : 0, 50, 100, 200, 500, 1000 µg/plate
Cycotoxic concentr. : > 1000 ug/plate
Metabolic activation : with and without
Result : negative
Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975)
Year : 1980
GLP : no data
Test substance : other TS: o-toluidine, no data on purity
Remark : Mutagenic response on urine extract (undefined urine-metabolites) after a
single orally dose of 300 mg/kg o-toluidine to male Sprague-Dawley rats
weakly positive
Result : Trial 1:
o-toluidine was not mutagenic in vitro
Trial 2:
urinary extract from rats fed with o-toluidine caused increased rats of
revertants in Salmonella Typhimurium TA 98 in the presence of S9-mix
UNEP PUBLICATIONS 181