o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

More documents

Recommendations

Info

OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 5.0 TOXICOKINETICS, METABOLISM AND DISTRIBUTION 128 In Vitro/in vivo : In vivo Type : Metabolism Species : rat Number of animals Males : Females : Doses Males : 50 mg/kg bw; 500 mg/kg bw see also freetext TC Females : Vehicle : other: corn oil Route of administration : gavage Exposure time : Product type guidance : Decision on results on acute tox. tests : Adverse effects on prolonged exposure : Half-lives : 1 st : 2 nd : 3 rd : Toxic behaviour : Deg. product : Method : other: see freetext TC Year : 1980 GLP : no data Test substance : other TS: see freetext TS and TC Result : Urinary excretion of 14C after a single 50 mg/kg oral dose of 14C-labelled o-toluidine hydrochloride was 94.7% within 72 hours. 37.4% unchanged ortho-toluidine was found within 72 hours. Conjugate as 4-amino-3-methylphenol was found in hydrolyzed urine totaled 51.7% within 72 hours. Metabolism of o-toluidine: Only a single component was found which was not found in control urine samples. This was identified as unchanged o-toluidine: 21.2% of the administered otoluidine appeared unchanged in the 24h urine. Total recovery of the unchanged isomer was not significantly increased at 48- or 72-h after treatment. Test condition : TEST ORGANISMS: - Animals: adult male Sprague Dawley rats - Weight at study initiation: 380-440g ADMINISTRATION and URINE EXAMINATIONS: - 9 animals were administered with a single dose of 50 mg ortho-[methyl- 14C]-toluidine hydrochloride/kg bw Urine samples were collected in glass tubes packed in flaked ice 6,12,24,48, and 72 after treatment. - 4 animals were administered with a single dose of 500 mg non-labelled otoluidine and 24h urine was collected. - 12 rats were administered with 1 ml/kg corn oil for 24h control urine EXAMINATIONS: Urine volume UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Urinary excretion of 14C hydrolized and unhydrolized urine was examined STATISTICAL ANALYSIS: Statistical differences between groups were determined using Student`s ttest Test substance : Test substance: ortho-[methyl-14C]-toluidine hydrochloride and o-toluidine, purity >=99 % Reliability : (1) valid without restriction Flag : Critical study for SIDS endpoint 13.05.2004 (128) In Vitro/in vivo : In vivo Type : Metabolism Species : rat Number of animals Males : Females : Doses Males : 50 or 400 mg/kg Females : Vehicle : physiol. saline Route of administration : s.c. Exposure time : Product type guidance : Decision on results on acute tox. tests : Adverse effects on prolonged exposure : Half-lives : 1 st : 2 nd : 3 rd : Toxic behaviour : Deg. product : Method : other: see freetext TC Year : 1980 GLP : no data Test substance : other TS: see freetext TS Result : EXCRETION: Following the administration of a single s.c. dose of 50 mg/kg or 400 mg/kg only low quantities of 14C were detected in the exhaled air. At both dose levels, urine formed the major excretory route, and the greater portion was excreted during the first 24h. Faecal excretion was low; approx. 2% of the low dose and 3% of the high dose were excreted in 48h. EXCRETION 14C after s.c.injection of o-[methyl-14C]toluidine in rats (2 rats used): DOSE.mg/kg.......50..... 50.........400....... 400 Urine, 24h...... 73.8.. 74.1........59.6......53.2 Urine, 48h..... 74.1... 75.6........83.0..... .75.4 Faeces, 24h..... ----..... ----..... ....1.9.........2.6 Faeces, 48h...... 2.3...... .1.9..... ....3.5.........3.0 14CO2, 24h...... 0.11.....0.15........0.75........1.2 14CO2, 48h....... 0.18.....0.27........1.46........1.26 Total rec. 48h.. 76.6.... 77.8..... ..88.0........79.7 DISTRIBUTION: Tissue concentration of radioactivity 48 h after s.c. injection of o-[methyl- 14C]toluidine in rats (2 rats used per dose): DOSE.mg/kg.......50........50.........400.........400 UNEP PUBLICATIONS 129
Page 1 and 2:
OECD SIDS o-TOLUIDINE FOREWORD INTR
Page 3 and 4:
OECD SIDS o-TOLUIDINE 11. Comments:
Page 5 and 6:
OECD SIDS o-TOLUIDINE and transitio
Page 7 and 8:
OECD SIDS o-TOLUIDINE countries), e
Page 9 and 10:
OECD SIDS o-TOLUIDINE 1.3 Physico-C
Page 11 and 12:
OECD SIDS o-TOLUIDINE methylene-bis
Page 13 and 14:
OECD SIDS o-TOLUIDINE Table 3 Photo
Page 15 and 16:
OECD SIDS o-TOLUIDINE With adapted
Page 17 and 18:
OECD SIDS o-TOLUIDINE Table 8 Geoac
Page 19 and 20:
OECD SIDS o-TOLUIDINE polluted site
Page 21 and 22:
OECD SIDS o-TOLUIDINE depending on
Page 23 and 24:
OECD SIDS o-TOLUIDINE prepared from
Page 25 and 26:
OECD SIDS o-TOLUIDINE 3.1.2 Acute T
Page 27 and 28:
OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
Page 29 and 30:
OECD SIDS o-TOLUIDINE Inhalation Th
Page 31 and 32:
OECD SIDS o-TOLUIDINE males or fema
Page 33 and 34:
OECD SIDS o-TOLUIDINE examination y
Page 35 and 36:
OECD SIDS o-TOLUIDINE Conclusion Th
Page 37 and 38:
OECD SIDS o-TOLUIDINE According to
Page 39 and 40:
OECD SIDS o-TOLUIDINE The lowest te
Page 41 and 42:
OECD SIDS o-TOLUIDINE 4.2 Terrestri
Page 43 and 44:
OECD SIDS o-TOLUIDINE 6 REFERENCES
Page 45 and 46:
OECD SIDS o-TOLUIDINE Bringmann G,
Page 47 and 48:
OECD SIDS o-TOLUIDINE Hecht SS, El-
Page 49 and 50:
OECD SIDS o-TOLUIDINE phase extract
Page 51 and 52:
OECD SIDS o-TOLUIDINE Stark M (1892
Page 53 and 54:
OECD SIDS o-TOLUIDINE I U C L I D D
Page 55 and 56:
OECD SIDS o-TOLUIDINE 1. GENERAL IN
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
OECD SIDS o-TOLUIDINE 2. PHYSICO-CH
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78: OECD SIDS o-TOLUIDINE 3. ENVIRONMEN
Page 105 and 106: OECD SIDS o-TOLUIDINE 4. ECOTOXICIT
Page 127: OECD SIDS o-TOLUIDINE 4. ECOTOXICIT
Page 131 and 132: OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 179 and 180:
OECD SIDS o-TOLUIDINE 5. TOXICITY I
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
OECD SIDS o-TOLUIDINE 6. REFERENCES
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297:
show all

o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?