o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 140 Insufficient documentation and/or Secondary literature 02.06.2004 (144) Type : LD50 Value : = 940 mg/kg bw Species : rat Strain : other: Carworth-Wistar Sex : male Number of animals : 5 Vehicle : no data Doses : individual doses not mentioned Method : other: see ME and TC Year : 1962 GLP : no Test substance : other TS: o-toluidine, no data on purity Method : according to Smyth et al., Am. Ind. Hyg. Ass. J. 23, 95-107 (1962), based upon mortalities during a 14-day observation period the most probable LD50 value and its fiducial range are estimated by the method of Thompson (1947) using the tables of Weil (1952) Result : LD50 = 940 mg/kg bw confidence limits as +- 1.96 standard deviation = 670 - 1310 mg/kg Test condition : TEST ORGANISMS: - Animals: Carworth-Wistar male rats - Age: 4 - 5 weeks - Weight at study initiation: 90 - 120 g ADMINISTRATION: - Route: gavage - Doses: dosages were arranged in a logarithmic series differing by a factor of two - Doses per time period: single dose at nonfasted animals - Post dose observation period: 14 days Reliability : (2) valid with restrictions no necropsy and no histopathological examinations were performed 02.06.2004 (145) Type : LD50 Value : = 2951 mg/kg bw Species : rat Strain : Osborne-Mendel Sex : male Number of animals : 10 Vehicle : water Doses : see freetext TC Method : other: single dose by stomach tube, 14-day observation period, calculation of LD50 with the Bliss probit method Year : 1969 GLP : no Test substance : other TS: o-toluidine-hydrochloridepurified by reccrystalisation (no further data on purity) Test condition : TEST ORGANISMS: - Animals: Osborne-Mendel male rats - Weight at study initiation: 250 g ADMINISTRATION: - Route: gavage - Doses: dosages in a series of 3 levels at 10 antilog unit UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 intervals with 10 animals at each level - Doses per time period: single dose - Post dose observation period: 14 days Reliability : (4) not assignable documentation insufficient for assessment 27.05.2004 (146) Type : LD50 Value : = 635 mg/kg bw Species : rat Strain : Wistar Sex : male Number of animals : Vehicle : water Doses : Method : Year : 1984 GLP : no data Test substance : other TS: o-toluidine, mo data on purity Reliability : (4) not assignable Insufficient documentation and/or Secondary literature 02.06.2004 (147) Type : other: methemoglobinemia Value : 200 mg/kg bw Species : rat Strain : Wistar Sex : female Number of animals : Vehicle : no data Doses : 200 mg/kg bw Method : other: single application by gavage, blood taken from heart or tail vein, immediately examination for methemoglobin according to the method of Evelyn-Malloy Year : 1984 GLP : no Test substance : other TS: o-toluidine, no data on purity Result : Single oral application of 200 mg/kg bw p-toluidine resulted in a methemoglobin level (max) of 11.6 % eight hours post application. Reliability : (2) valid with restrictions no data on number of animals, no data on purity of the substance, no data on GLP, standard deviation not given 09.06.2004 (148) Type : LD50 Value : = 840 mg/kg bw Species : rabbit Strain : Sex : Number of animals : Vehicle : Doses : Method : other: no data Year : 1967 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable Insufficient documentation and/or Secondary literature UNEP PUBLICATIONS 141
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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