o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 95-53-4 DATE: 07.01.2005 82 Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 21.06.2004 (55) (56) Type of measurement : background concentration Media : surface water Concentration : Method : Method : - Samples taken 1997-1998 - 3 sampling sites at the Rhine km 359.3 (LfU-measuring site in Karlsruhe), km 685.8 (ARW-measuring site in Cologne), km 732.1 (ARW-measuring site in Duesseldorf), each 6 samples - 1 sampling site at the Wahnbach valley reservoir, tributary to the Rhine south of Cologne - 2 sampling sites at the Elbe km 4.1 (Schmielka, German-Czech border, 8 samples), km 474.7 (Schnackenburg site, close to estuary, 5 samples) - 1 sampling site at the Mulde, 7.6 km from the confluent with the Elbe in Dessau (5 samples) - There is also a sampling site at the Wupper (only mentioned by Reifferscheid and Grummt 2000) - Sampling volume 80 l in 24 h, stored and transported at 4 °C - Several tests on genotoxicity - Determination of about 40 aromatic amines and azo compounds Result : - o-Toluidine was detected in the rivers Rhine and Elbe in 1997 and 1998 (Grummt 2000). - The o-toluidine concentration varied largely from sampling to sampling (detection limit 0.001 µg/l) in both Rhine and Elbe. o-Toluidine was repeatedly detected at several sampling sites, including the most upstream sampling sites (Karlsruhe on the river Rhine, Schmilka on the river Elbe) (DVGW 2004). - The o-toluidine concentration was below 30 ng/l in the Rhine. At the Elbe river, Schmilka was the most polluted site with the o-toluidine concentration occasionally at 0.1 µg/l (Reifferscheid and Grummt 2000). Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 20.06.2004 (57) (58) (59) Type of measurement : concentration at contaminated site Media : surface water Concentration : Method : Capillary zone electrophoresis Remark : Chromatogramme presented only as an example that method is applicable. As stated by the authors, result of preliminary test (presumably single data, no replicate). No information on interferences present in enviromental samples. No information on sampling, e.g. type of sample, time, country, and river (if information was correct: Since use of textile dyes releasing o-toluidine is prohibited in the EU, this is either an outdated information or samples were taken in India). No check of substance identification in environmental sample by independent, relevant method (e.g. MS). Result : With a detection limit of 1-3 µg/l, it was reported that o-toluidine could be present in river water downstream leather industries (probably in India). Test condition : Limit of detection 1-3 µg/l Reliability : (3) invalid Documentation insufficient for assesment 07.06.2004 (60) UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 95-53-4 DATE: 07.01.2005 Type of measurement : concentration at contaminated site Media : other: tobacco smoke Concentration : Method : GC/MS Result : o-Toluidine and several other amines occur in tobacco smoke Reliability : (2) valid with restrictions Flag : Critical study for SIDS endpoint 02.03.2004 (61) Type of measurement : concentration at contaminated site Media : other: tobacco smoke Concentration : Method : Result : o-Toluidine occurs in tobacco smoke. The ring-substituted aromatic amines of tobacco smoke are most likely formed during pyrolysis. The authors state that the concentrations of the most aromatic amines (e.g. o-toluidine) are ranging from 10-100 ug/kg tobacco dry weight. Reliability : (2) valid with restrictions Data from peer-reviewed handbook or collection of data Flag : Critical study for SIDS endpoint 07.06.2004 (62) Type of measurement : concentration at contaminated site Media : other: tobacco smoke Concentration : Method : Result : o-Toluidine occurs in tobacco smoke. Formation may be due to pyrolysis. On the other hand, nonenzymatic browning reactions occur which lead to the formation of nitrogen heterocycles (e.g. pyrrazols) from sugars and amino acids. these products may be transferred into the smoke. Reliability : (2) valid with restrictions Data from peer-reviewed handbook or collection of data Flag : Critical study for SIDS endpoint 24.02.2004 (63) Type of measurement : concentration at contaminated site Media : other: tobacco smoke Concentration : Method : Result : In cigarette smoke, the o-toluidine content is reported to be 32 ng/cigarette Reliability : (4) not assignable Secondary literature Flag : Critical study for SIDS endpoint 24.02.2004 (3) Type of measurement : concentration at contaminated site Media : other: tobacco smoke Concentration : Method : Calculation Result : The daily uptake of o-toluidine is about 3.6 µg/d by smokers (25 cigarettes/d) in the USA Reliability : (2) valid with restrictions accepted calculation method Flag : Critical study for SIDS endpoint 24.02.2004 (64) UNEP PUBLICATIONS 83
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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