o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
232<br />
Exposure period : single dose<br />
Doses : 15-30 % der LD50<br />
Result : positive<br />
Method : other: thymidine incorporation inhibiting screening system<br />
Year : 1981<br />
GLP : no data<br />
Test substance : other TS: no data on purity<br />
Reliability : (4) not assignable<br />
special test method<br />
10.10.2003 (327) (328) (329) (330)<br />
Type : Micronucleus assay<br />
Species : mouse<br />
Sex : no data<br />
Strain : B6C3F1<br />
Route of admin. : i.p.<br />
Exposure period : twice 0, 24h<br />
Doses : 80% of LD50 value<br />
Result : negative<br />
Method : other: according Heddle and Salamone, 1980<br />
Year : 1981<br />
GLP : no data<br />
Test substance : other TS: o-toluidine hydrochloride, see freetext TC<br />
Test condition : This study is part of a International Collaborative Program, published as:<br />
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation<br />
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981<br />
CHEMICALS:<br />
42 coded chemicals were investigated in short-term tests for<br />
cancerogenicity in different laboratories<br />
It should be suggested that only 100%-pure chemicals should be used<br />
when evaluating a test system.<br />
In the present work the compound with code no 41 is declared as otoluidine<br />
hydrochloride, whereas in an the overall summary of this program<br />
code no. 41 is declared as o-toluidine.<br />
In the first phase mice were injected intraperitoneally with 80% of the LD50<br />
dose at 0 and 24h, and samples were taken at 48, 72, and 96 hours. While<br />
there was no increase in micronuclei the test substance were retestet with<br />
one injection of 100 and 50 % of the LD50 dose, and samples were taken<br />
at 30, 48 and 72 hours.<br />
Reliability : (4) not assignable<br />
Method-Evaluation, no specific data on given doses<br />
18.05.2004 (152) (331)<br />
Type : Micronucleus assay<br />
Species : mouse<br />
Sex : male/female<br />
Strain : CD-1<br />
Route of admin. : i.p.<br />
Exposure period : twice apart. 24h<br />
Doses : 0.04, 0.08, 0.16 mg/kg bw in DMSO<br />
Result : negative<br />
Method : other: according Schmid, 1973<br />
Year : 1981<br />
GLP : no data<br />
Test substance : other TS: see freetext TC<br />
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