o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
GLP : no data<br />
Test substance : other TS: see freetext TC<br />
Test condition : This study is part of a International Collaborative Program, published as:<br />
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation<br />
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981<br />
CHEMICALS:<br />
42 coded chemicals were investigated in short-term tests for<br />
cancerogenicity in different laboratories<br />
It should be suggested that only 100%-pure chemicals should be used<br />
when evaluating a test system.<br />
---In the present work the compound with code no 41 is declared as otoluidine<br />
hydrochloride, whereas in an the overall summary of this program<br />
code no. 41 is declared as o-toluidine.<br />
METABOLIC ACTIVATION:<br />
S9 mix - liver homogenates from with either PB or Aroclor 1254 induced<br />
rats<br />
Reliability : (4) not assignable<br />
Method-Evaluation, only one strain, insufficient documentation, unclear<br />
use: o-toluidine or o-toluidine hydrochloride<br />
15.07.2004 (152) (221)<br />
Type : Bacterial forward mutation assay<br />
System of testing : Salmonella typhimurium BA 13, BA 9<br />
Test concentration : 0-9 µmol<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : with<br />
Result : positive<br />
Method : other: L-arabinose-resistence test with S typhimurium<br />
Year : 1988<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Method : The "Ara test" uses an araD mutant select changes from L-arabinose<br />
sensitivity (Ara-s) to L-arabinose resistance (Ara-r) in a medium containing<br />
L-arabinose plus glycerol. The Ara test is based on the fact that mutations<br />
in the structural gene for L-ribulose-5-phosphate 4-epimerase not only<br />
block the utilization of L-arabinose as a carbon source, but also lead to the<br />
accumulation of a toxic intermediate(presumably L-ribolose 5-phosphate).<br />
Bacterial growth is thus inhibited in the presence of L-arabinose and a<br />
carbon source unable to repress the araBAD operon.<br />
METABOLIC ACTIVATION:<br />
S9 mix liver homogenates from Aroclor 1254 induced rats<br />
Result : Significant mutagenic response with 30% S9 in the S9 mix<br />
Reliability : (4) not assignable<br />
special study; method evaluation, insufficient documentation<br />
15.07.2004 (222)<br />
Type : Bacterial gene mutation assay<br />
System of testing : Salmonella typhimurium TA 98, TA 100; Escherichia Coli WP2,<br />
WP2uvrA(P)<br />
Test concentration : up to 500 µg/plate<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : with and without<br />
Result : positive<br />
Method : other: Evaluation of mutagenesis assay using two species of bacteria<br />
Year : 1981<br />
<strong>UNEP</strong> PUBLICATIONS 187
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