o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 176 Method-Evaluation, only 4 concentrations tested, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (186) (152) Type : Ames test System of testing : Salmonella typhimurium TA 92, TA 98, TA 100, TA 1535, TA 1537, TA 1538 Test concentration : 0.2, 2, 20, 200 and 2000 µg/plate Cycotoxic concentr. : preliminary cytotoxicity test Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) Year : 1981 GLP : no data Test substance : other TS: see freetext TC Method : The method was basically described by Ames et al. but included a period of incubation of test compound and bacteria, or test compound, bacteria, and S9 mix. Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar rats Reliability : (2) valid with restrictions Method-Evaluation, well documented, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (187) (152) Type : Ames test System of testing : Salmonella typhimurium TA 98, TA 100, TA 1537 Test concentration : 100, 500, 2000, 5000 µg/plate in DMSO Cycotoxic concentr. : 5000 µg/plate Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced male Sprague- Dawley rats Three concentrations of S9-mix were used to test compounds that gave negative results (0.05, 0.1, and 0.3 ml of S9/ml of mix). Reliability : (4) not assignable Method-Evaluation, only three strains tested, only four concentrations tested, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (188) Type : Ames test System of testing : Salmonella typhimurium TA 100, TA 1535, TA 1538 Test concentration : 1, 2, 3, 4, 5 µmol/plate Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) Year : 1979 GLP : no data Test substance : other TS: o-toluidine, purified by destillation Result : o-toluidine was inactive in all tested strains with or without activation by rat liver homogenate Test condition : METABOLIC ACTIVATION: S9 mix liver homogenates from Aroclor 1254 induced male Fischer 344 rats POSITIVE CONTROLS: N-methyl-N´-nitro-N-nitrosoguandine picrolonic acid chrysene quinoline CONCENTRATIONS/VEHICLE Various concentrations of test compound in 50µl of DMSO were added to 0.1 ml of an overnight nutrient broth culture of the bacterial tester strain. Reliability : (4) not assignable 3 strains only, documentation insufficient for assessment 15.07.2004 (189) Type : Ames test System of testing : Salmonella typhimurium TA 98, TA 100 Test concentration : data not given Cycotoxic concentr. : Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) Year : 1987 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : o-toluidine was non-mutagenic in presence or absence of rat liver S9 in TA100 and TA98 data of positive controls not shown Test condition : METABOLIC ACTIVATION: S9 mix liver homogenates from Aroclor 1254 induced male albino rats UNEP PUBLICATIONS 177
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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