o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 204 Result : positive Method : other: Anchorage-independent survival assay according Suk et al., 1984 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable Documentation insufficient for assessment, Method-Evaluation 15.07.2004 (269) Type : other: lambda-induction assay System of testing : lysogenic strains of E. coli carried lambda prophage Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : with Result : negative Method : other: according Hollstein et al., 1979 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Remark : Zorotest Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (270) (152) Type : other: lambda-induction assay System of testing : lysogenic strains of E. coli carried lambda prophage Test concentration : 500, 2500 µg/ml Cycotoxic concentr. : > 2500 µg/ml Metabolic activation : with Result : positive Method : other: according Moreau et al., 1976 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (271) Type : HGPRT assay System of testing : CHO-Zellen Test concentration : 0, 0.1, 0.25, 0,50 µl/ml DMSO Cycotoxic concentr. : >= 0.25 µg/ml DMSO Metabolic activation : with and without Result : ambiguous Method : other: experiment performed in roller bottles, treatment time: 4 days, metabolic activation by cocultivation with irradated primary Syrian hamster embryo cells Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : For o-toluidine a conclusion could not yet be reached for mutation at the Na/K-ATPase locus. Reliability : (3) invalid assay system evaluation, unsuitable test method 15.07.2004 (173) (272) Type : HGPRT assay System of testing : Chinese hamster V79 Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: modified method as described by Lee and Webber, 1982 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable assay system evaluation, detailed data such as concentration range cytotoxicity and results in detail are not reported 15.07.2004 (173) (273) Type : Mammalian cell gene mutation assay System of testing : Chinese hamster V79 cells Test concentration : 0, 0.1, 1.0, 5.0 mM in DMSO Cycotoxic concentr. : > 5 mM Metabolic activation : with and without Result : ambiguous Method : other: Kuroki, T. et al. (1977): Cancer Res. 37, 1044-1050 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : Although marginal increase in mutation frequency (0.5 - 0.9 per 10E6 survivors) was observed there were no dose-response relationship. UNEP PUBLICATIONS 205
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE I U C L I D D
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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