o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
26) from about 1.2 µg/l to 2.8 µg/l, and in exposed workers (n = 42-43) from
about 15 µg/l to 99 µg/l. Levels of o-toluidine hemoglobin adducts were 3.5
ng/g hemoglobin in unexposed workers and 41 ng/g hemoglobin in
exposed workers (Ward et al., 1996).
Reliability : (2) valid with restrictions
Basic data given
Flag : Critical study for SIDS endpoint
03.06.2004 (388) (391)
Type of experience : other: Health record from industry and smoking
Result : 45 workers from 3 chemical plants (presumably in Germany) were
examined. The urinary o-toluidine concentrations were 0.4 µg/l in
occupationally exposed non-smokers and 0.6 µg/l in smokers (difference
not significant). However, there were significant increases in the urinary otoluidine
levels in unexposed smokers (mean 1.7 µg/l, n = 8), compared to
unexposed non-smokers (0.0 µg/l, n = 8).
Reliability : (2) valid with restrictions
Basic data given
Flag : Critical study for SIDS endpoint
03.06.2004 (410)
Type of experience : other: Human exposure to o-toluidine via azo dyes
Result : An OSHA report from 1982 states (cited according to NTP, 2003):
"Consumer exposure to o-toluidine may possibly occur from residues
present in commercial dyes used on textiles." (NTP, 2003). In the EU, the
use of azo dyes releasing o-toluidine on degradation, is not permitted for
textiles and other consumer articles (EU , 1976,; 2002,; 2003). The same
conclusion has been drawn by the IARC (2000).
Reliability : (2) valid with restrictions
Data from handbook or collection of data
Flag : Critical study for SIDS endpoint
03.06.2004 (411) (412) (413) (41) (3)
Type of experience : other: Biological monitoring (human milk)
Remark : The authors explain their observation with the occurrence of aromatic
amines in tobacco smoke and some foods.
Exposure to (environmental) tobacco smoke not conclusively determined
Result : In human milk from 7 smokers and 24 non-smokers, there were