o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 202 Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Interpretation A positive result was taken where a consistent reduction in survival was observed at one or more concentrations between WP2 and the repair deficient strains. Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (262) Type : DNA damage and repair assay System of testing : E. coli WP2; WP67 uvrA polA; CM871 uvrA recA lexA Test concentration : 0, 500, 1000, 2500 µg/ml (-S9); 0, 500, 1000, 2500 µg/ml (+S9); Cycotoxic concentr. : >2500 µg/ml (-S9); >=2500 µg/ml (+S9) Metabolic activation : with and without Result : negative Method : other: differential killing assay according Green and Tweats, 1979 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Remark : Author concluded that the differential killing assay is less sensitive than a mutation assay Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats Interpretation A positive result was taken where a consistent reduction in survival was observed at one or more concentrations between WP2 and the repair deficient strains. Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (263) UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Type : DNA damage and repair assay System of testing : Escherichia coli pol A- and pol A+ Test concentration : 20 µl Cycotoxic concentr. : no data Metabolic activation : with and without Result : positive Method : other: standard disc diffusion assay according Slater et al. (1971) and Rosenkranz and Leifer (1979) Year : 1979 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : o-toluidine was positive in the pol A- assay without metabolic activation Reliability : (2) valid with restrictions Method Evaluation 15.07.2004 (264) (265) (266) Type : other: DNA deletion events by intrachromosomal recombination (DEL) assay System of testing : Saccharomyces cerevisiae RS112 Test concentration : 0.0, 3.0, 4.0, 5.0, 6.0 mg/ml Cycotoxic concentr. : >= 5.0 mg/ml Metabolic activation : no data Result : positive Method : other: DEL recombination assay Year : 1999 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : o-toluidine induced deletion and generated free radicals in yeast Reliability : (4) not assignable special study, no validated test method 15.07.2004 (267) Type : other: DNA-adduct formation in Salmonella typhimurium TA98 in the presence of norharman System of testing : Salmonella typhimurium TA98 Test concentration : 100 µg/plate Cycotoxic concentr. : no data Metabolic activation : with Result : positive Method : other: 32 P-post labelling method Year : 1996 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : 32P-post-labelling analysis: Salmonell typhimurium TA 98 (4 ml)overnight culture was incubated with 8 mg norharman and 4 mg toluidine in the presence of 20 ml S9-mix for 6 hours at 37°C 3 adduct spots were detectedat a Relative Adduct Labelling (RAL) of 3.74/10(exp.8) nucleotides. Neither Norharman nor o-toluidine themselve gave any evidence of adduct. Reliability : (4) not assignable special study, only one dose tested 15.07.2004 (268) Type : other: Enhancement of anchorage-independent survival System of testing : Rauscher leukemia virus (RLV) infected Fischer rat-embryo (RIFRE) cells Test concentration : 1, 5, 10, 50, 100, 500 µg/ml Cycotoxic concentr. : >= 500 µg/ml Metabolic activation : no data UNEP PUBLICATIONS 203
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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OECD SIDS o-TOLUIDINE 5. TOXICITY I
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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