o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 192 Cycotoxic concentr. : no data Metabolic activation : with and without Result : positive Method : other: according Kada et al. (1978) Year : 1981 GLP : no data Test substance : other TS: see freetext TC Result : o-toluidine was tested positive with metabolic activation with S9 mix from rats and yellowtail fish Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with PCB induced rats and commercial available liver homogenates from yellowtail fish Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (232) Type : Gene mutation in Saccharomyces cerevisiae System of testing : Strain XV185-14C Test concentration : up to 3 µg/ml Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other Year : 1981 GLP : no data Test substance : other TS: see freetext TC Remark : mitotic gene conversion Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced rats; growing cells were treated only in absence of the S9 system Reliability : (4) not assignable UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Method-Evaluation, no data on cytotoxicity, unclear use: o-toluidine or otoluidine hydrochloride 15.07.2004 (152) (233) (234) Type : Gene mutation in Saccharomyces cerevisiae System of testing : Strain C658-K42 Test concentration : 0, 0.5, 1.0, 3.0 mg/ml Cycotoxic concentr. : +S9: >3.0 mg/ml; -S9: >0.5 mg/ml Metabolic activation : with and without Result : positive Method : other Year : 1989 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : positive with S9-mix at 3.0 mg/ml Reliability : (4) not assignable Insufficient documentation 15.07.2004 (235) Type : Gene mutation in Saccharomyces cerevisiae System of testing : RS112 Test concentration : 0, 100, 1000, 2000, 3000, 5000 µg/ml Cycotoxic concentr. : >=3000 µg/ml Metabolic activation : with and without Result : positive Method : other: DEL recombination assay Year : 1994 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : o-toluidine increased the frequency of DEL recombination 2.6-fold in the absence of S9 and more than 5-fold in the presence of S9. In the absence of S9 an increase of DEL recombination frequency was first seen at a concentration of 3 mg/ml whereas in the presence of S9 an increase appears already at 1 mg/ml. The frequency if ICR was not increased according the definition. Reliability : (2) valid with restrictions Method Evaluation 15.07.2004 (236) (237) Type : Gene mutation in Saccharomyces cerevisiae System of testing : strain JD1 Test concentration : no data, lowest effective concentration: 50 µg/ml Cycotoxic concentr. : >50 µg/ml Metabolic activation : with and without Result : positive Method : other: Detection of Mitotic Gene Convertants in the yeast S. cerevisiae strain JD1 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Result : Mitotic gene conversion without S9 mix. Lowest effective concentration was 50 µg/ml. Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for UNEP PUBLICATIONS 193
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE methylene-bis
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OECD SIDS o-TOLUIDINE Table 3 Photo
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OECD SIDS o-TOLUIDINE With adapted
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OECD SIDS o-TOLUIDINE 3.1.2 Acute T
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE Conclusion Th
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OECD SIDS o-TOLUIDINE The lowest te
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OECD SIDS o-TOLUIDINE 4.2 Terrestri
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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