o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 224 System of testing : Mouse kidney C3H2K cells Test concentration : 1.0 - 100 µg Cycotoxic concentr. : no data Metabolic activation : without Result : negative Method : other: according Yoshikura et al., 1979 Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. Reliability : (4) not assignable Method-Evaluation, unsuitable test system, unclear use: o-toluidine or otoluidine hydrochloride 15.07.2004 (152) (314) Type : other: inhibition of metabolic cooperation System of testing : Chinese hamster V79 cells Test concentration : no data, see remarks Cycotoxic concentr. : no data Metabolic activation : no data Result : positive Method : other Year : 1986 GLP : no data Test substance : no data Remark : inhibition of metabolic cooperation at concentration higher than 0.5 mM Reliability : (4) not assignable Method-Evaluation, insufficient documentation 15.07.2004 (315) Type : other: inhibition of metabolic cooperation System of testing : Chinese hamster V79 cells Test concentration : 16, 47, 157, 470, 1570, 4700 µM Cycotoxic concentr. : 4700 µM Metabolic activation : without Result : positive Method : other Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable Method-Evaluation 15.07.2004 (316) (317) (318) (319) Type : other: inhibition of metabolic cooperation UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 System of testing : Chinese hamster V79 cells Test concentration : 0, 0.5, 1.0, 2.0, 5.0, 10 mM Cycotoxic concentr. : preliminary cytotoxicity test Metabolic activation : Result : positive Method : other: according Yotti et al., 1979 Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : Very slight increase in recovery of 6Tgr cells. Reliability : (4) not assignable Method-Evaluation 15.07.2004 (318) (320) Type : other: inhibition of metabolic cooperation System of testing : Chinese hamster V79 cells Test concentration : 0.5, 1.0, 2.5, 5, 10, 15, 20, 25 µg/ml Cycotoxic concentr. : = 20 µg/ml Metabolic activation : Result : positive Method : Year : 1985 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable Method-Evaluation 15.07.2004 (316) (317) (318) Type : other: initiator t-RNA acceptance assay System of testing : different t-RNA preperations Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : no data Result : positive Method : other: Hradec, J. (1988): Carcinogenesis 9, 837-842 Year : 1988 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable special study, insufficient documentation 15.07.2004 (321) (322) 5.6 GENETIC TOXICITY ‘IN VIVO‘ Type : Drosophila SLRL test Species : Drosophila melanogaster Sex : male Strain : other: Canton S wild Route of admin. : other: larval feeding Exposure period : from larvae to adult Doses : 0, 500 ppm in water Result : negative Method : other: according Zimmering, Environ. Mutagen. 7, 87 (1985): see also freetext ME Year : 1989 GLP : no data UNEP PUBLICATIONS 225
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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OECD SIDS o-TOLUIDINE 5. TOXICITY I
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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