o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
250
Route of admin. : oral feed
Exposure period : 91 days
Frequency of treatm. : continuously
Post exposure period :
Doses : 15 - 24 mg/animal (reduced for toxicity at 7.5 - 12 mg/animal)
Result :
Control group :
Method : other: see freetext TC
Year : 1947
GLP : no
Test substance : other TS: no data on purity
Result : 3/10 animals showed changes in the mucous membrane of the bladder
with metaplasia and early epithelial proliferation
Test condition : 10 rats were given a basic diet of rice flour with addition of a slice of carrot
about every other day, and o-toluidine was added to the rice flour.
Reliability : (4) not assignable
documentation insufficient for assessment
12.02.2004 (160) (161) (356)
Species : rat
Sex : no data
Strain : no data
Route of admin. : s.c.
Exposure period : 85 weeks
Frequency of treatm. : once/week
Post exposure period :
Doses : 0, 30 mg
Result :
Control group : yes
Method : other: no data
Year : 1978
GLP : no data
Test substance : other TS: no data
Result : No of animals with tumors: 12/30 treated animals and 10/48 controls, no
further information
Test condition : No. of animals: 75 controls; 50 treated
Reliability : (4) not assignable
Insufficient documentation and/or Secondary literature
12.02.2004 (362)
Species : rat
Sex : male/female
Strain : Sprague-Dawley
Route of admin. : s.c.
Exposure period : 24 months
Frequency of treatm. : once / week
Post exposure period : no
Doses : 0, 25, 75 mg/kg bw/day in peanut oil
Result :
Control group : yes, concurrent vehicle
Method : other: carcinogenicity see freetext TC
Year : 1981
GLP : no
Test substance : as prescribed by 1.1 - 1.4
Result : MORTALITY: no deaths occurred
positive controls: significant reduced surviving time probabely due to early
appearance of malignant tumours
UNEP PUBLICATIONS