o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
184<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Remark : Norharman-complex<br />
Result : positive only in presence of norharman with S9 mix<br />
Reliability : (4) not assignable<br />
only two strains used, mutagenicity tested in presence of co-mutagen<br />
norharman<br />
15.07.2004 (205) (206)<br />
Type : Ames test<br />
System of testing : Salmonella typhimurium TA 97, TA 98, TA 100, TA 104<br />
Test concentration : 3 µl/plate undiluted<br />
Cycotoxic concentr. :<br />
Metabolic activation : with and without<br />
Result : ambiguous<br />
Method : other: according to Maron et al., Mutat. Res. 113, 173 (1983), plate<br />
incorporation methodology, DMSO as neg. contr., pos. contr: 4nitroquinoline-N-oxide,2-aminofluorene<br />
Year : 1986<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Result : positive in TA100 with and without rat liver S9 mix<br />
Reliability : (4) not assignable<br />
details of the results were not reported, no data on purity of TS and no<br />
information about GLP<br />
15.07.2004 (207)<br />
Type : Ames test<br />
System of testing : Salmonella typhimurium TA98<br />
Test concentration : 0,40, 120, 200 µg/plate<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : with<br />
Result : positive<br />
Method : other: as described by Nagao et al., 1977<br />
Year : 1977<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Remark : Norharman-complex<br />
Result : o-Toluidine was shown to be a very strong mutagen in the presence of<br />
Norharman and S9 mix<br />
Reliability : (4) not assignable<br />
only one strains used,in presence of co-mutagen norharman<br />
15.07.2004 (208) (209) (210) (211) (212)<br />
Type : Ames test<br />
System of testing : Salmonella typhimurium (see freetext TC)<br />
Test concentration : no data<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: modified Ames test according Cline and McMahon, 1977, Res.<br />
Commun. Chem. Pathol. Pharmacol. 16, 523-<strong>53</strong>3; pos. control: 2-AAF,<br />
Streptozotocin<br />
Year : 1981<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Test condition : The modified Ames gradient plate test employed ten bacterial strains: eight<br />
<strong>UNEP</strong> PUBLICATIONS
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