o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
264<br />
kidneys, ovaries, heart and lung<br />
for effects on parent animals : see chapter 5.8.1<br />
Reliability : (4) not assignable<br />
documentation insufficient for assessment, no sufficient information on<br />
methods and results<br />
Flag : Critical study for SIDS endpoint<br />
26.05.2004 (163)<br />
Species : mouse<br />
Sex : female<br />
Strain : Balb/c<br />
Route of admin. : s.c.<br />
Exposure period : last week of pregnancy<br />
Frequency of treatm. : 4 - 5 injections<br />
Duration of test :<br />
Doses : 2 mg/animal<br />
Control group : yes<br />
Method : other: tumor development in progeny<br />
Year : 1974<br />
GLP : no<br />
Test substance : other TS: o-tolidine see also RM<br />
Remark : This work is cited in RTECS and as second literature in MAK-Begründung<br />
1986, but test substance is not clearly defined. In the english translation<br />
test substance is called o-tolidine.<br />
Result : After treatment with OT, half of the 16 mice studied were found to have<br />
tumors: adenomas of the lung in six and tumors of the mammary glands in<br />
five.<br />
Culturing of the kidneys of the progeny from the treated females resulted in<br />
specific hyperplastic pretoumerous alterations of the respective epithelium.<br />
Reliability : (4) not assignable<br />
Insufficient documentation and/or Secondary literature/ Test substance<br />
questionable<br />
Flag : Critical study for SIDS endpoint<br />
26.05.2004 (363) (364)<br />
Species : mouse<br />
Sex : female<br />
Strain : Balb/c<br />
Route of admin. : s.c.<br />
Exposure period : whole period of gestation<br />
Frequency of treatm. : every 4-5 days<br />
Duration of test :<br />
Doses : 2 mg in sunflower oil/animal<br />
Control group :<br />
Method : other: see freetect ME<br />
Year : 1969<br />
GLP : no<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Method : Females were injected every 4-5 days during pregnancy. one-two days<br />
before the delivery the pregnant animals were killed and embryonic tissues<br />
were explantated in organ cultures. Explants were examined by histological<br />
and autoradiographic methods.<br />
Result : Whereas in the control cultures there was only degeneration, necrobiosis<br />
and necrosis, in the cultures from treated embryos marked irregular<br />
hyperplasia was seen from day 3 or 4 and occasionally even focal growth.<br />
Instead of necrotic glomeruli, cysts developed; the epithelium of the tubuli<br />
contoti proliferated into the lumen, the epithelial cells were hypercchromatic<br />
and mitoses could be seen<br />
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