o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 236 - Weight at study initiation: - No. of animals per dose: 4/sampling time ADMINISTRATION: - Vehicle: olive oil - Duration of test: - Frequency of treatment: single - Sampling times and number of samples: 0 (zero time control), 3, 8, 24 h; samples from 8 organs: stomach, colon, liver, kidney, urinary bladder, brain, lung, bone marrow; evaluation of 50 nuclei/organ - Control groups: untreated animals EXAMINATIONS: - Clinical observations: pharmacotoxic signs until sacrifice - Organs examined at necropsy: examination of stomach, colon, liver, kidney, urinary bladder, brain, lung, bone marrow for changes in size, color, texture - Histopathological examination was conducted when positive results were obtained in the alkaline SCG assay therefore a small portion of each organ was fixed in 10% formaldehyde, dehydrated, and embedded in paraffin. - Criteria for evaluating results: positive when significant increase of length of DNA migration, test for significance: Dunnett test, p 99 % Result : Stomach, colon, kidney, and urinary bladder were positive in the SCG assay. Test condition : TEST ORGANISMS: - Age: 7 weeks - Weight at study initiation: - No. of animals per dose: 4/sampling time ADMINISTRATION: - Vehicle: olive oil - Duration of test: - Frequency of treatment: single - Sampling times and number of samples: 0 (zero time control), 3, 8, 24 h; samples from 8 organs: stomach, colon, liver, kidney, urinary bladder, brain, lung, bone marrow; UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 evaluation of 50 nuclei/organ - Control groups: untreated animals EXAMINATIONS: - Clinical observations: pharmacotoxic signs until sacrifice - Organs examined at necropsy: examination of stomach, colon, liver, kidney, urinary bladder, brain, lung, bone marrow for changes in size, color, texture - Histopathological examination was conducted when positive results were obtained in the alkaline SCG assay therefore a small portion of each organ was fixed in 10% formaldehyde, dehydrated, and embedded in paraffin. - Criteria for evaluating results: positive when significant increase of length of DNA migration, test for significance: Dunnett test, p
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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