o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 268 "toluidine, aniline, etc.". 102 cases of bladder cancer were observed among industrial workers between 1895 and 1985. Most of these persons had been exposed to 2naphthylamine either alone or together with other aromatic amines; in addition, 21 cases were mentioned for which the expiosure had involved "toluidine, aniline etc." Reliability : (2) valid with restrictions basic data given Flag : Critical study for SIDS endpoint 27.05.2004 (400) (401) Type of experience : Health records from industry Remark : During repair of machines a fitter was accidently exposed aginst o-toluidine (exposure route probabely: inhalation, concentration not given). Treatment with tolonium chloride reduced methemoglobinemia fron 39,6 % to 2.6 % Source : BASF AG Reliability : (2) valid with restrictions no data on concentration in the air Flag : Critical study for SIDS endpoint 19.02.2004 (402) Type of experience : other: Biological monitoring (blood) Remark : In the Boston cohort, the o-toluidine hemoglobine adduct level was 0.25- 0.45 ng/g hemoglobin for different groups of smokers, and 0.09 ng/g hemoglobin for non-smokers. In the Turin cohort, the o-toluidinehemoglobine-adduct level was 0.29 ng/g hemoglobin in smokers, and 0.17 ng/g hemoglobin in non-smokers. Reliability : (2) valid with restrictions basic data given Flag : Critical study for SIDS endpoint 03.06.2004 (403) Type of experience : Health records from industry Remark : In a group of 35 male workers who were engaged between 1924 and 1953 in the production of 4-chloro-o-toluidine from o-toluidine, no tumors in the urinary bladder were found. Test substance : no data Reliability : (4) not assignable no data on level and duration of exposure 03.06.2004 (404) Type of experience : other: o-Toluidine exposure levels and health record from industry Remark : The study of Khlebnikova et al. (1970) [Problems of industrial hygiene and health status of workers engaged in the production of o-toluidine] was published in Russian with a German translation. However, this translation does not cover all data on o-toluidine, and most information on o-toluidine was cited according to IARC (2000). Result : Workers of a chemical plant in the former USSR were generally exposed to o-toluidine concentrations of 6-20 mg/m³, with the highest level up to 29 mg/m³ (Maximum permissible level for o-toluidine: 3 mg/m³). During shift, there was a dermal deposition of 0.01-0.03 mg/100cm² of skin, and patches of cloth collected 0.1 mg/100 cm² of textile. Cytoscopic examination of the urinary bladder of 75/81 workers engaged in the production of o/p-toluidine showed 2/75 patients with urinary bladder papilomas and some patients with changes in the urinary bladder mucous membranes. Test substance : no data UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Reliability : (2) valid with restrictions basic data given Flag : Critical study for SIDS endpoint 03.06.2004 (41) (405) Type of experience : other: Health record from industry and smoking Remark : Cancer incidence was investigated in a cohort of 700 workers employed at a Connecticut chemical plant between mid-1965 and 1989. The plant produced a variety of chemicals, including arylamines such as dichlorobenzidine (DCB), o-dianisidine, o-tolidine, but not benzidine. Benzidine production ceased prior to mid-1965. The principal finding was a statistically significant increase in the standardized incidence ratio (SIR) for bladder cancer in men (SIR = 8.3; confidence interval, 3.3 to 17.0). Based on an exposure classification system developed by a panel of former and current employees, the observed association between bladder cancer cases and exposure to arylamines increased with increasing exposure (SIRs = 0.0, 5.5, 16.4, for none, low, or moderate levels of exposure, respectively). Smoking probably contributed to the bladder cancer risk, as all case subjects were known to be current or former cigarette smokers. Reliability : (2) valid with restrictions basic data given Flag : Critical study for SIDS endpoint 03.06.2004 (406) Type of experience : Direct observation, poisoning incidents Remark : A worker transferred toluidine from one open vessel to another and , in the process inhaled enough vapour to cause mild poisoning, lost consiousness and remained unconscious in toluine-contaminated clothes until evening. The patient was cyanotic and exhaled high levels of toluidine. the next day he urinated only very painfully and the urine contained blood. The strangury reached its peak on day 5. On day 8 the urinary complains regressed but blood was detectable in the urine until day 10. Full recovery required 5 weeks. Reliability : (4) not assignable secondary literature Flag : Critical study for SIDS endpoint 19.02.2004 (407) Type of experience : other: Biological monitoring (urine) Remark : Dye manufacturing plant in the USA: During the mid-1940s, industrial hygiene measurments were taken. Breathing zone and area samples for o-toluidine were consitently below 0.5 ppm (2.9 mg/m3). Medical surveillance included the determination of otoluidine concentrations in the urine. In 1948, urine of workers contained otoluidine at concentrations of
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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