o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 182 Test condition : two trials were reported: 1. Ames test in vitro TS: o-toluidine, no name of the solvent but used as negative control, positive controls not mentioned, performed with and without S9-mix 2. Ames test of Urine extract 300 mg/kg bw o-toluidiene was fed once to male Sprague-Dawley rats (8- 12 animals), urine was collected over 24 hours and extracts were prepared and used for the Ames test in the presence and in the abbsence of S9-mix. Urine extract from rats to which no chemical was given served as negative control Metabolic activation: S9 mix was prepared from male Sprague-Dawley rat livers treated with polychlorinated biphenyl. Reliability : (4) not assignable Insufficient documentation: no positive controls, only 2 strains used, solvent not mentioned no data on purity of Ts and not performed under GLP 15.07.2004 (200) Type : Ames test System of testing : Salmonella typhimurium TA 98, TA 100, TA 1535 Test concentration : Cycotoxic concentr. : Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) Year : 1980 GLP : no data Test substance : other TS: o-toluidine, purity: 97-99 % Test condition : METABOLIC ACTIVATION: S9 mix liver homogenates from Aroclor 1254 induced Sprague-Dawley rats SOLUTION in DMSO Reliability : (4) not assignable documentation insufficient for assessment, no data on concentration 15.07.2004 (201) Type : Ames test System of testing : Salmonella typhimurium TA 98, TA 100, TA 1537 Test concentration : without S9 and with S9-mix and norharman: 50, 100, 500, 1000 µg/plate in DMSO Cycotoxic concentr. : no data Metabolic activation : with and without Result : positive Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) : preincubation methodology, solvent control, no positive control Year : 1981 GLP : no data Test substance : other TS: o-toluidine hydrochloride Remark : positive only in presence of norharman and S9-mix Reliability : (4) not assignable test description insufficient for assessment, in presence of co-mutagen norharman, 3 strains only 15.07.2004 (202) Type : Ames test System of testing : Salmonella typhimurium TA 1538 Test concentration : 0, 50, 100 ug/plate in DMSO UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975), pos. control: acetylaminofluorene Year : 1977 GLP : no data Test substance : other TS: o-toluidine, no data on purity Reliability : (4) not assignable Insufficient documentation and/or Secondary literature, one strain only, cytotoxicity not given 15.07.2004 (203) (195) Type : Ames test System of testing : Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538 Test concentration : 4, 20, 100, 500 and 2500 µg/plate Cycotoxic concentr. : no data Metabolic activation : with Result : positive Method : other: according to Ames et al.,Proc Natl Acad Sci USA,70 (1973) Year : 1981 GLP : no data Test substance : other TS: see freetext TC Result : positive response with TA1538 Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced male Sprague Dawley rats, ratio of cofactor solution :S9 was 3:1. Positive Controls: TA1535 and TA100 - 1,3-propane-sultone TA1538 and TA98 - 2-acetylaminofluorene TA1537 - 9-aminoacridine Reliability : (4) not assignable Method-Evaluation, insufficient documentation, no cytotoxicity, no detailed results given, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (204) Type : Ames test System of testing : Salmonella typhimurium TA 98, TA 100 Test concentration : Cycotoxic concentr. : Metabolic activation : with Result : positive Method : other: according to Maron et al., Mutat. Res. 113, 173 (1983) Year : 1989 UNEP PUBLICATIONS 183
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE countries), e
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OECD SIDS o-TOLUIDINE 1.3 Physico-C
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OECD SIDS o-TOLUIDINE methylene-bis
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OECD SIDS o-TOLUIDINE Table 3 Photo
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OECD SIDS o-TOLUIDINE With adapted
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OECD SIDS o-TOLUIDINE prepared from
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OECD SIDS o-TOLUIDINE 3.1.2 Acute T
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OECD SIDS o-TOLUIDINE 3.1.4 Sensiti
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OECD SIDS o-TOLUIDINE Inhalation Th
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OECD SIDS o-TOLUIDINE males or fema
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OECD SIDS o-TOLUIDINE examination y
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OECD SIDS o-TOLUIDINE Conclusion Th
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OECD SIDS o-TOLUIDINE According to
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OECD SIDS o-TOLUIDINE The lowest te
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OECD SIDS o-TOLUIDINE 4.2 Terrestri
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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OECD SIDS o-TOLUIDINE 5. TOXICITY I
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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