o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 134 - Animals: male Wistar rats - body weight: 200 - 250 g - Number of animals: 6 per group ADMINISTRATION / EXPOSURE - Duration of test/exposure: 3 days - Type of exposure: i.p. - Vehicle/control: sunflower oil Rats were fasted for 12h after the last administration before being killed. Rats were decapitated on the fourth day, livers, kidneys and lungs were immediately excised, weighed and homogenized. PARAMETERS INVESTIGATED: Cytochrome P450, Cytochrome b5, NADPH cytochrome c reductase, Aryl hydrocarbon hydrolase (AHH), Aminopyrine demethylase, Epoxide hydrolase, Glutathione-S-transferase, Ratio of Glutathione-S-transferase to AHH activities and Ratio of Epoxide Hydrolase to AHH activities STATISTICS: Analysis were performed (method not mentioned); differences were assumed to be significant when p
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Hepatic DNA, RNA binding were determined according Cooper(1977), The tools of Biochemistry pp. 56 and Burton(1956), Biochem. J. 62, 315 Total protein binding was determined by method as described Hughes (1986) Carcinogenesis 7, 3-8; Protein was determined by the method of Lowery (1951) J. Biol. Chem. 193, 265 Reliability : (2) valid with restrictions study meets gtenerally acceptable principles 13.05.2004 (131) In Vitro/in vivo : In vivo Type : Metabolism Species : rat Number of animals Males : Females : Doses Males : 0, 10, 100 mg/kg bw/day in corn oil Females : Vehicle : other: corn oil Route of administration : i.p. Exposure time : 7 day(s) Product type guidance : Decision on results on acute tox. tests : Adverse effects on prolonged exposure : Half-lives : 1 st : 2 nd : 3 rd : Toxic behaviour : Deg. product : Method : other: see freetext ME Year : 1988 GLP : no data Test substance : other TS: o-toluidine, purity: 99 % Method : MaleSprague-Dawley rats were i.p. injected with 10 and 100 mg o-toluidine /kg bw/day dissolved in corn oil for 7 consecutive days . Rats were killed 24 hours after the last injection. The study was carried out to examine the capacity to affect xenobiotic transformation in rats Result : 1) Dose dependant significant effects of o-toluidine on hepatic cytochrome P-450 monooxygenase activities and related enzymes (low dose, high dose versus control): Cytochrom P-450 (nmol/mg protein): 0.88, 0.92 versus 0.68 Ethoxyresorufin-O-deethylase (pmol/mg protein): 103, 1100 versus 57 Ethoxycoumarin-O-deethylase (pmol/mg protein): 574, 1852 versus 420 Aldrin epoxidase (nmol/min/mg protein): 3.94, 4.05 versus 2.95 2) Significant effects of treatment by 100 mg o-toluidine on ---activity of androstenedione hydoxylases (nmoles/min/mg protein): 7-alpha-hydroxyandrost-4-ene-3,17-dione (7-alpha-OHA) 6-beta-hydroxyandrost-4-ene-3,17-dione (6-beta-OHA) 16-beta-hydroxyandrost-4-ene-3,17-dione (16-beta-OHA) 16-alpha-hydroxyandrost-4-ene-3,17-dione (16-alpha-OHA) ---and on testosterone formation (test-f) (nmoles/min/mg protein) treatment versus control: 7-alpha-OHA: 0.18 versus 0.12 UNEP PUBLICATIONS 135
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE I U C L I D D
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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