o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 180 Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 Chemicals: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix liver homogenates from Aroclor 1254 induced rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (196) Type : Ames test System of testing : Salmonella typhimurium TA 100, TA 1535, TA 1537, TA 1538 Test concentration : 0.1, 1, 10, 100, 500, 2000 µg/plate in DMSO Cycotoxic concentr. : preliminary cytotoxicity test Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) Year : 1981 GLP : no data Test substance : other TS: see freetext TC Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar rats Reliability : (2) valid with restrictions Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (197) Type : Ames test System of testing : Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538 Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) Year : 1981 GLP : no data Test substance : other TS: see freetext TC UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Test condition : This study is part of a International Collaborative Program, published as: Evaluation of Short-Term Tests for Cancerogens Progress in Mutation Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981 CHEMICALS: 42 coded chemicals were investigated in short-term tests for cancerogenicity in different laboratories It should be suggested that only 100%-pure chemicals should be used when evaluating a test system. ---In the present work the compound with code no 41 is declared as otoluidine hydrochloride, whereas in an the overall summary of this program code no. 41 is declared as o-toluidine. METABOLIC ACTIVATION: S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar rats Reliability : (4) not assignable Method-Evaluation, documentation insufficient, unclear use: o-toluidine or o-toluidine hydrochloride 15.07.2004 (152) (198) Type : Ames test System of testing : Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538 Test concentration : 1000 µg/plate (highest tested concentration) Cycotoxic concentr. : no data Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) Year : 1979 GLP : no data Test substance : other TS: o-toluidine, no data on purity Test condition : METABOLIC ACTIVATION: S9 mix liver homogenates from Aroclor 1254 induced male Sprague- Dawley rats solvent control and positive controls not mentioned. Reliability : (4) not assignable concentration range not given, no negative and positive controls reported, cytotoxic concentration not reported, no data on purity of TS 15.07.2004 (199) Type : Ames test System of testing : Salmonella typhimurium TA 98, TA 100 Test concentration : 0, 50, 100, 200, 500, 1000 µg/plate Cycotoxic concentr. : > 1000 ug/plate Metabolic activation : with and without Result : negative Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975) Year : 1980 GLP : no data Test substance : other TS: o-toluidine, no data on purity Remark : Mutagenic response on urine extract (undefined urine-metabolites) after a single orally dose of 300 mg/kg o-toluidine to male Sprague-Dawley rats weakly positive Result : Trial 1: o-toluidine was not mutagenic in vitro Trial 2: urinary extract from rats fed with o-toluidine caused increased rats of revertants in Salmonella Typhimurium TA 98 in the presence of S9-mix UNEP PUBLICATIONS 181
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE I U C L I D D
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OECD SIDS o-TOLUIDINE 1. GENERAL IN
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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