o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 272 Type of experience : other: Biological monitoring (blood) Method : Hemoglobin adducts of aromatic amines in children from three differentsized Bavarian towns were examined Remark : Exposure to (environmental) tobacco smoke not conclusively determined Result : No influence of exposure to environmental tobacco smoke (determined by interview) on o-toluidine hemoglobin adduct levels was found, but the highest adduct levels were observed in the largest town. Reliability : (4) not assignable Documentation insufficient for assessment Flag : Critical study for SIDS endpoint 03.06.2004 (416) Type of experience : other: Biological monitoring (blood) Result : Significant differences were found between smokers (n = 12) and nonsmokers (n = 10). The o-toluidine hemoglobine adduct level was tripled in smokers (0.10 ng/g hemoglobin), compared to non-smokers (0.034 ng/g hemoglobin). Reliability : (2) valid with restrictions Basic data given Flag : Critical study for SIDS endpoint 03.06.2004 (417) Type of experience : other: Biological monitoring (blood) Result : The hemoglobin adduct background level of toluidine (no isomer specified) is 1-10 µg/l for the general population due to tobacco smoke. Reliability : (2) valid with restrictions Data from handbook or collection of data Flag : Critical study for SIDS endpoint 03.06.2004 (418) 5.11 ADDITIONAL REMARKS Type : other: CICAD, 1998, is available and used as review. 04.01.2005 Type : other Remark : Biological monitoring toa assess human exposure to o-toluidine indicates tgat absorption may occur through inhalation and dermal contact; however, quantitative information was not identified. o-toluidiene bindes to hemoglobin. N-acetylated metabolites of o-toluidine are eliminated in the urine. Reliability : (2) valid with restrictions valid review Flag : Critical study for SIDS endpoint 04.01.2005 (14) Type : other: Hematotoxicity Remark : Nine adult cats (older then 24 weeks) were administered with 0.25 mmol/kg bw (approx. 27 mg/kg) o-toluidine for a single i.v. injection. Methemoglobin determinatations 1, 2, 3, 4, 5 hours after injection: 57.4, 63.9, 64.5, 63.3, 57.1 % methemoglobin respectively. Mean 61.3 and mean max. 70.1% methemoglobin. Methemoglobin in untreated rats: mean1.1% (max.3%) UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Reliability : (2) valid with restrictions application route is not suitable for the human situation 27.05.2004 (419) Type : other: Hemoglobin binding Remark : After single oral dose of 0.6 mmol/kg (ca.=64.2 mg/kg) o-toluidine to female Wistar rats and 1 mmol/kg (ca.=107 mg/kg) to female B6C3F1 mice by gavage a hemoglobin binding index (HBI: mmol/mol Hb/dose (mmol/kg)) of 4.0 in rats and 2.1 in mice was found. Reliability : (2) valid with restrictions meets general accepted scientific criteria, but rat and mouse are less susceptible than human 18.02.2004 (420) Type : other: blood protein adducts Remark : Investigations of hemoglobin and albumin adducts after single administration in rats Result : HB adducts showed a linear relationship for dose Test condition : male SD rats received o-toluidine i.p.: 10,20,40,50,100 mg/kg bw: max OT binding 4h for alb and 24h for Hb Reliability : (2) valid with restrictions meets general accepted scintific principles 18.02.2004 (421) (422) (423) (424) (425) Type : other: hemoglobin binding Remark : After single oral dose of 0.5 mmol/kg (ca.= 54 mg/kg) o-toluidine to female Wistar rats by gavage a hemoglobin binding index (HBI: mmol/mol Hb/dose (mmol/kg)) of 4.0 in rats was found. Reliability : (2) valid with restrictions meets general accepted scientical principles 18.02.2004 (426) (427) Type : other: methemoglobin in cats Remark : 5 cats were injected intraperitoneally with o-toluidine solutions in corn oil in doses from 1 to 80 mg/kg b.w. From increased of hemoglobin concentrations a dose effect correlation should be determined; maximal value was received after 20 mg/kg bw: 9.7 % In doses above 30 mg/kg no further increase in methemoglobin formation were determined. Reliability : (4) not assignable documentation insufficient for assessmnet 18.02.2004 (428) UNEP PUBLICATIONS 273
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE phase extract
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OECD SIDS o-TOLUIDINE Stark M (1892
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OECD SIDS o-TOLUIDINE I U C L I D D
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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