o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
Method-Evaluation, no data on cytotoxicity, unclear use: o-toluidine or otoluidine<br />
hydrochloride<br />
15.07.2004 (152) (233) (234)<br />
Type : Gene mutation in Saccharomyces cerevisiae<br />
System of testing : Strain C658-K42<br />
Test concentration : 0, 0.5, 1.0, 3.0 mg/ml<br />
Cycotoxic concentr. : +S9: >3.0 mg/ml; -S9: >0.5 mg/ml<br />
Metabolic activation : with and without<br />
Result : positive<br />
Method : other<br />
Year : 1989<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Result : positive with S9-mix at 3.0 mg/ml<br />
Reliability : (4) not assignable<br />
Insufficient documentation<br />
15.07.2004 (235)<br />
Type : Gene mutation in Saccharomyces cerevisiae<br />
System of testing : RS112<br />
Test concentration : 0, 100, 1000, 2000, 3000, 5000 µg/ml<br />
Cycotoxic concentr. : >=3000 µg/ml<br />
Metabolic activation : with and without<br />
Result : positive<br />
Method : other: DEL recombination assay<br />
Year : 1994<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Result : o-toluidine increased the frequency of DEL recombination 2.6-fold in the<br />
absence of S9 and more than 5-fold in the presence of S9. In the absence<br />
of S9 an increase of DEL recombination frequency was first seen at a<br />
concentration of 3 mg/ml whereas in the presence of S9 an increase<br />
appears already at 1 mg/ml. The frequency if ICR was not increased<br />
according the definition.<br />
Reliability : (2) valid with restrictions<br />
Method Evaluation<br />
15.07.2004 (236) (237)<br />
Type : Gene mutation in Saccharomyces cerevisiae<br />
System of testing : strain JD1<br />
Test concentration : no data, lowest effective concentration: 50 µg/ml<br />
Cycotoxic concentr. : >50 µg/ml<br />
Metabolic activation : with and without<br />
Result : positive<br />
Method : other: Detection of Mitotic Gene Convertants in the yeast S. cerevisiae<br />
strain JD1<br />
Year : 1981<br />
GLP : no data<br />
Test substance : other TS: see freetext TC<br />
Result : Mitotic gene conversion without S9 mix. Lowest effective concentration was<br />
50 µg/ml.<br />
Test condition : This study is part of a International Collaborative Program, published as:<br />
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation<br />
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981<br />
CHEMICALS:<br />
42 coded chemicals were investigated in short-term tests for<br />
<strong>UNEP</strong> PUBLICATIONS 193