o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 Tests were performed with and without exogenous metabolic activation (liver cells from with Aroclor induced male rats S9 mix). Reliability : (2) valid with restrictions special investigation 13.02.2004 (381) Species : other: mouse; mammalian cell transformation assay Sex : Strain : other: AKR leukemia virus infected NIH Swiss mouse embryo (AKH-NIH- ME) cells Route of admin. : Exposure period : Frequency of treatm. : Post exposure period : Doses : 1.0, 10.0 µg/ml culture medium Result : positive Control group : yes Method : other: according Rhim et al., 1973 Year : 1974 GLP : no Test substance : other TS: no data on purity Test condition : Chemicals were administered to the AKR leukemia virus infected NIH Swiss mouse embryo (AKH-NIH-ME) cells in petri dishes. After an incubating period of 7 days the plates were fed with chemical free medium and incubated 14 days more. Then the colonies were fixed and stained and observed for morphologic alterations. Tests were performed without exogenous metabolic activation Tests on cytotoxicity were performed Negative controls: untreated and solvent Reliability : (4) not assignable Documentation insufficient for assessment 01.12.2003 (382) (383) 5.8.1 TOXICITY TO FERTILITY Type : other: effects on fertility on parent animals Species : rat Sex : male/female Strain : no data Route of admin. : dermal Exposure period : 4 month Frequency of treatm. : 4 h/day Premating exposure period Male : Female : Duration of test : No. of generation : studies Doses : 8, 80 mg/kg bw Control group : yes Method : other: see TC Year : 1983 GLP : no data Test substance : other TS: o-toluidine, no data on purity Result : Effects on treated animals (P): ---increased cell numbers of the spermatogenetic tissues 262 UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 ---no differences on spermatogenesis during the recovery period ---increased number of corpus luteum in ovaries ---no differences on fertility and number of implants observed for effects on progeny (F1): see chapter 5.8.2 Test condition : o-toluidine was administered to 2/3 of the tail skin in male and female albino rats. number of animals: 15 per group doses: 8, 80 mg/kg bw treatment period: 4 month frequency: daily with a 4 hour duration After treatment period one part of animals were killed and genitals were examined. The other part were mated with untreated rats. Examinations: body weights spermatogenesis organ weights blood no detailed information on parameters investigated available Reliability : (4) not assignable documentation insufficient for assessment, no sufficient information on methods and results 26.05.2004 (163) 5.8.2 DEVELOPMENTAL TOXICITY/TERATOGENICITY Species : rat Sex : male/female Strain : no data Route of admin. : dermal Exposure period : 4 months Frequency of treatm. : daily Duration of test : 4 hours/day Doses : 8 and 80 mg/kg Control group : yes Method : other: effects on progeny (F1), see freetext ME) Year : 1983 GLP : no data Test substance : other TS: o-toluidine, no data on purity Method : o-toluidine was administered to 2/3 of the tail skin in male and female albino rats. number of animals: 15 per group doses: 8, 80 mg/kg bw treatment period: 4 month frequency: daily with a 4 hour duration After treatment period one part of animals were killed and genitals were examined. The other part were mated with untreated rats. Examinations: body weights spermatogenesis organ weights blood no detailed information on parameters investigated available Result : Effects on progeny (F1) ---progeny of high dose females: body weight gain was reduced in the f1 generation: this effect was reversible after 2 month ---progeny of high dosed male or females: slight differences on relative organ weights in the f1 generation: UNEP PUBLICATIONS 263
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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OECD SIDS o-TOLUIDINE I U C L I D D
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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