o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 142 02.06.2004 (144) 5.1.2 ACUTE INHALATION TOXICITY Type : LC50 Value : = 862 ppm Species : rat Strain : Sprague-Dawley Sex : male Number of animals : 10 Vehicle : other: air Doses : 492, 606, 722, 799, 848, 931, 1000 ppm (approx. 2184, 2691, 3206, 3548, 3765, 4134, 4440 mg/m³) Exposure time : 4 hour(s) Method : other: see freetext ME and TC Year : 1981 GLP : no data Test substance : other TS: 99.7 % Method : LC50 calculated with the Probit Analysis, Finney DJ, 3rd ed. Cambridge University Press. Result : The LC50 was determined to be 862 ppm (corresponding to 3827 mg/m³) with 95% confidence limits between 816 and 913 ppm. The slope of the regression analysis was 18.7 MORTALITY: number of animals per dose / timepoint (10 animals per group) Concentration (ppm) .Mean........SD.....days post exposure.. .total No of .................... ..0....1....2....3....4..... deaths -492. ........68... .....0....0....0....0....0.......0/10 .606...... ...44.........0....0....0....0....0.......0/10 .722....... 180.........0....0....1....0....0.......1/10 .799........ .86.........0....1....0....0....1.......2/10 .848......... 59.........0....1....4....1....0.......6/10 .931........199.........2....1....1....1....0.......5/10 1000........372........2....8.. ..-....-... .-......10/10 CLINICAL SIGNS: Compound related signs of intoxication, observed during and immediately following exposure, consisted of tremor, slight to moderate cyanosis, muscle spasm, labored breathing, slight to moderate corneal opacity, prostation and semi- prostation, and reddish-brown nasal discharge. Clinical signs observed at 24 hours or longer consisted of corneal opacity, prostration, lethargy, labored breathing, pallor, hypothermie, reddish-brown nasal discharge and stained wet perinia. The clinical manifestations of o-toluidine were generally dose-related. BODY WEIGHTS: body weight losses of 6 to 22 % were observed 1 to 3 days post exposure, with normal weight gains occurring thereafter (individual animal data not given). Test condition : TEST ORGANISMS: - Age: 8 weeks - Weight at study initiation: 230 - 260 g - Number of animals: 10/dose UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 GENERATION OF TEST ATMOSPHERE The atmosphere was generated by passing nitrogen over o-toluidine liquid contained in a 3-neck round-bottom flask heated from 115 to 120°C.the vapor/aerosol was diluted with humified and O2-enriched houseline air and passed into the exposure chamber. Test atmosphere was regularly controlled. STUDY DESIGN: - Type of exposure: head-only - Exposure period: 4 hours - Post exposure observation period: 14 d DETERMINATION OF: - body weights: daily - clinical signs: daily Reliability : (2) valid with restrictions individual animal data not given, no necropsy and no histopathological examinations were performed/reported Flag : Critical study for SIDS endpoint 05.02.2004 (149) Type : other: Inhalation Hazard Test Value : Species : rat Strain : Sex : male/female Number of animals : 6 Vehicle : other: air Doses : saturated vapor Exposure time : 8 hour(s) Method : other: Inhalation Hazard Test, see also freetext TC Year : 1962 GLP : no Test substance : other TS: o-toluidine, no data on purity Result : After an inhalation period of 8 hours all animals survived the two week observation period. Test condition : Concentrated vapor inhalation consists of subjecting groups of six male or female albino rats to a flowing stream of vapor-loaded air. The vapor-air mixture is generated by passing 2.5 liters/minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 ml of the test material contained in a gas-washing bottle. Inhalations are continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation period killing about half the number of rats within 14 days is defined. For inhalation periods of ten, five and two minutes in duration, a static technique is used, whereby 50 to 100 grams of material, spread over a shallow tray 200 square inches in area, is placed in a 120 liter sealed chamber for at least 24 hours. Six rats are then rapidly introduced by means of a drawer-type cage designed to minimize vapor loss. This static technique, continued for a maximum of eight hours if necessary, is also employed for mixtures of liquids and solids. Observation period: 14 days Reliability : (4) not assignable not according current standart, exposure concentration not given, no signs of intoxication reported, no necropsy and no histopathological examinations were performed/reported 02.06.2004 (145) Type : other: IRT Value : UNEP PUBLICATIONS 143
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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