o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
202
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
---In the present work the compound with code no 41 is declared as otoluidine
hydrochloride, whereas in an the overall summary of this program
code no. 41 is declared as o-toluidine.
METABOLIC ACTIVATION:
S9 mix - liver homogenates from with Aroclor 1254 induced rats
Interpretation
A positive result was taken where a consistent reduction in survival was
observed at one or more concentrations between WP2 and the repair
deficient strains.
Reliability : (2) valid with restrictions
Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride
15.07.2004 (152) (262)
Type : DNA damage and repair assay
System of testing : E. coli WP2; WP67 uvrA polA; CM871 uvrA recA lexA
Test concentration : 0, 500, 1000, 2500 µg/ml (-S9); 0, 500, 1000, 2500 µg/ml (+S9);
Cycotoxic concentr. : >2500 µg/ml (-S9); >=2500 µg/ml (+S9)
Metabolic activation : with and without
Result : negative
Method : other: differential killing assay according Green and Tweats, 1979
Year : 1981
GLP : no data
Test substance : other TS: see freetext TC
Remark : Author concluded that the differential killing assay is less sensitive than a
mutation assay
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
---In the present work the compound with code no 41 is declared as otoluidine
hydrochloride, whereas in an the overall summary of this program
code no. 41 is declared as o-toluidine.
METABOLIC ACTIVATION:
S9 mix - liver homogenates from with Aroclor 1254 induced rats
Interpretation
A positive result was taken where a consistent reduction in survival was
observed at one or more concentrations between WP2 and the repair
deficient strains.
Reliability : (2) valid with restrictions
Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride
15.07.2004 (152) (263)
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