o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
5.0 TOXICOKINETICS, METABOLISM AND DISTRIBUTION
128
In Vitro/in vivo : In vivo
Type : Metabolism
Species : rat
Number of animals
Males :
Females :
Doses
Males : 50 mg/kg bw; 500 mg/kg bw see also freetext TC
Females :
Vehicle : other: corn oil
Route of administration : gavage
Exposure time :
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Method : other: see freetext TC
Year : 1980
GLP : no data
Test substance : other TS: see freetext TS and TC
Result : Urinary excretion of 14C after a single 50 mg/kg oral dose of 14C-labelled
o-toluidine hydrochloride was 94.7% within 72 hours.
37.4% unchanged ortho-toluidine was found within 72 hours.
Conjugate as 4-amino-3-methylphenol was found in hydrolyzed urine
totaled 51.7% within 72 hours.
Metabolism of o-toluidine:
Only a single component was found which was not found in control urine
samples.
This was identified as unchanged o-toluidine: 21.2% of the administered otoluidine
appeared unchanged in the 24h urine. Total recovery of the
unchanged isomer was not significantly increased at 48- or 72-h after
treatment.
Test condition : TEST ORGANISMS:
- Animals: adult male Sprague Dawley rats
- Weight at study initiation: 380-440g
ADMINISTRATION and URINE EXAMINATIONS:
- 9 animals were administered with a single dose of 50 mg ortho-[methyl-
14C]-toluidine hydrochloride/kg bw
Urine samples were collected in glass tubes packed in flaked ice
6,12,24,48, and 72 after treatment.
- 4 animals were administered with a single dose of 500 mg non-labelled otoluidine
and 24h urine was collected.
- 12 rats were administered with 1 ml/kg corn oil for 24h control urine
EXAMINATIONS:
Urine volume
UNEP PUBLICATIONS