o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
Reliability : (2) valid with restrictions
application route is not suitable for the human situation
27.05.2004 (419)
Type : other: Hemoglobin binding
Remark : After single oral dose of 0.6 mmol/kg (ca.=64.2 mg/kg)
o-toluidine to female Wistar rats and 1 mmol/kg (ca.=107
mg/kg) to female B6C3F1 mice by gavage a hemoglobin binding
index (HBI: mmol/mol Hb/dose (mmol/kg)) of 4.0 in rats and
2.1 in mice was found.
Reliability : (2) valid with restrictions
meets general accepted scientific criteria, but rat and mouse are less
susceptible than human
18.02.2004 (420)
Type : other: blood protein adducts
Remark : Investigations of hemoglobin and albumin adducts after single
administration in rats
Result : HB adducts showed a linear relationship for dose
Test condition : male SD rats received o-toluidine i.p.: 10,20,40,50,100 mg/kg bw:
max OT binding 4h for alb and 24h for Hb
Reliability : (2) valid with restrictions
meets general accepted scintific principles
18.02.2004 (421) (422) (423) (424) (425)
Type : other: hemoglobin binding
Remark : After single oral dose of 0.5 mmol/kg (ca.= 54 mg/kg)
o-toluidine to female Wistar rats by gavage a hemoglobin binding index
(HBI: mmol/mol Hb/dose (mmol/kg)) of 4.0 in rats was found.
Reliability : (2) valid with restrictions
meets general accepted scientical principles
18.02.2004 (426) (427)
Type : other: methemoglobin in cats
Remark : 5 cats were injected intraperitoneally with o-toluidine solutions in corn oil in
doses from 1 to 80 mg/kg b.w.
From increased of hemoglobin concentrations a dose effect correlation
should be determined; maximal value was received after 20 mg/kg bw: 9.7
%
In doses above 30 mg/kg no further increase in methemoglobin formation
were determined.
Reliability : (4) not assignable
documentation insufficient for assessmnet
18.02.2004 (428)
UNEP PUBLICATIONS 273