o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
Reliability : (2) valid with restrictions<br />
basic data given<br />
Flag : Critical study for SIDS endpoint<br />
03.06.2004 (41) (405)<br />
Type of experience : other: Health record from industry and smoking<br />
Remark : Cancer incidence was investigated in a cohort of 700 workers employed at<br />
a Connecticut chemical plant between mid-1965 and 1989. The plant<br />
produced a variety of chemicals, including arylamines such as<br />
dichlorobenzidine (DCB), o-dianisidine, o-tolidine, but not benzidine.<br />
Benzidine production ceased prior to mid-1965. The principal finding was a<br />
statistically significant increase in the standardized incidence ratio (SIR) for<br />
bladder cancer in men (SIR = 8.3; confidence interval, 3.3 to 17.0). Based<br />
on an exposure classification system developed by a panel of former and<br />
current employees, the observed association between bladder cancer<br />
cases and exposure to arylamines increased with increasing exposure<br />
(SIRs = 0.0, 5.5, 16.4, for none, low, or moderate levels of exposure,<br />
respectively). Smoking probably contributed to the bladder cancer risk, as<br />
all case subjects were known to be current or former cigarette smokers.<br />
Reliability : (2) valid with restrictions<br />
basic data given<br />
Flag : Critical study for SIDS endpoint<br />
03.06.2004 (406)<br />
Type of experience : Direct observation, poisoning incidents<br />
Remark : A worker transferred toluidine from one open vessel to another and , in the<br />
process inhaled enough vapour to cause mild poisoning, lost consiousness<br />
and remained unconscious in toluine-contaminated clothes until evening.<br />
The patient was cyanotic and exhaled high levels of toluidine. the next day<br />
he urinated only very painfully and the urine contained blood. The<br />
strangury reached its peak on day 5. On day 8 the urinary complains<br />
regressed but blood was detectable in the urine until day 10. Full recovery<br />
required 5 weeks.<br />
Reliability : (4) not assignable<br />
secondary literature<br />
Flag : Critical study for SIDS endpoint<br />
19.02.2004 (407)<br />
Type of experience : other: Biological monitoring (urine)<br />
Remark : Dye manufacturing plant in the USA:<br />
During the mid-1940s, industrial hygiene measurments were taken.<br />
Breathing zone and area samples for o-toluidine were consitently below 0.5<br />
ppm (2.9 mg/m3). Medical surveillance included the determination of otoluidine<br />
concentrations in the urine. In 1948, urine of workers contained otoluidine<br />
at concentrations of
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