o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
194<br />
cancerogenicity in different laboratories<br />
It should be suggested that only 100%-pure chemicals should be used<br />
when evaluating a test system.<br />
---In the present work the compound with code no 41 is declared as otoluidine<br />
hydrochloride, whereas in an the overall summary of this program<br />
code no. 41 is declared as o-toluidine.<br />
METABOLIC ACTIVATION:<br />
S9 mix - liver homogenates from with Aroclor 1254 induced rats<br />
Reliability : (2) valid with restrictions<br />
Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride<br />
15.07.2004 (152) (238)<br />
Type : Gene mutation in Saccharomyces cerevisiae<br />
System of testing : Saccharomyces cerevisiae JD 1<br />
Test concentration : up to 2000 µg/ml<br />
Cycotoxic concentr. : > 2000 µg/ml in DMSO<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: according Davis et al., 1975, Mutation Res. 29, 301<br />
Year : 1985<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Method : Assays were performed with or without S9 microsomal fraction obtained<br />
from a liver homogenate from rats pretreated with Aroclor 1254 and in a<br />
yeast assay optimized for cytochrome P-450 levels in the absence of an<br />
exogenous activation system.<br />
Remark : mitotic gene conversion<br />
Result : The addition of o-toluidine at concentrations up to 2000 µg/ml to stationaryphase<br />
or log-phase cultures of S.cerevisiae JD1 did not show any<br />
consistent increase in the rate of mitotic gene conversion, either with or<br />
without the addition of rat liver S9 fraction or in the optimized yeast P-450<br />
assay.<br />
Reliability : (4) not assignable<br />
no validated test system<br />
15.07.2004 (239) (234) (240)<br />
Type : Gene mutation in Saccharomyces cerevisiae<br />
System of testing : strain D61-M, D6<br />
Test concentration : up to 5000 µg/ml<br />
Cycotoxic concentr. :<br />
Metabolic activation : with and without<br />
Result : positive<br />
Method : other: according Kelly and Parry (1983)<br />
Year : 1985<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Result : o-toluidine is capable of inducing mitotic chromosome aneuploidy in yeast,<br />
the lowest positive concentration was 600 µg/ml<br />
Test substance : Ten chemicals were tested for there ability to induce mitotic aneuploidy,<br />
point mutation and mitotic segration in strains D6 and D61-M<br />
Reliability : (4) not assignable<br />
no validated test system<br />
15.07.2004 (234) (241)<br />
Type : Gene mutation in Saccharomyces cerevisiae<br />
System of testing : strain D61.M<br />
Test concentration : 0, 0.5, 0.74, 0.99, 1.23, 1.48, 1.72, 1.96 µg/ml<br />
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