o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
1) intact skin:<br />
erythema:<br />
24 hrs: 2 /2 /4+n /2 /2 /2 // 2.3<br />
48 hrs: 2 /2 /4+n /2 /1 /1 // 2.0<br />
72 hrs: 2+s/1+s/4+np /1+s/1+s/1+s // 1.7<br />
8d : 0+s/0+s/4+npl/0+s/0+s/0+s // 0.7<br />
edema:<br />
24 hrs: 2/2/2 /2/2/2 // 2.0<br />
48 hrs: 0/0/2*/0/0/0 // 0.3<br />
72 hrs: 0/0/2*/0/0/0 // 0.3<br />
8d : 0/0/2*/0/0/0 // 0.3<br />
Total recovery within the following days<br />
No mortallity occurred. There were no clinical signs of systemic toxicity<br />
from the dermal exposure.<br />
2) scarified skin<br />
erythema<br />
24 hrs: 2 /2 /4+n/2+n/2+n /4+n // 2.7<br />
72 hrs: 2+s /2+s /4+n/2+n/2+n /4+n // 2.7<br />
8d : 1+s+n/1+s+n/4+n/4+n/1+s+n/4+n // 2.6<br />
edema<br />
24 hrs: 2/2/2/2/2/3 // 2.2<br />
72 hrs: 2/1/2/1/2/2 // 1.7<br />
8d : 1/1/2/1/1/2 // 1.3<br />
Necrotic tissue damage was observed.<br />
In summary:<br />
The treatment led to slight or moderate erythema and moderate edema in<br />
5/6 animals up to 72 and 24 hours after start of the application. At 72 hrs<br />
after application these animals exhibited scaling which was still observed<br />
on day 8. Necrosis (soft, parchmentlike, or leathery) was observed in 1/6<br />
animals until termination of the study. the clinical finding of necrosis was<br />
confirmed by macroscopic pathology.<br />
Source : BASF AG<br />
Conclusion : corrosive (moderate)<br />
The conclusion is based on the skin necrosis observed in 1/6 animals.<br />
If the evaluation would take only account of the 5 animals not displaying<br />
skin necrosis, the test substance would be regarded as non-irritant<br />
according to current criteria.<br />
Thus theconclusion of this test may be more stringent than one derived<br />
from a four-hour semi occluded application as required by the current<br />
OECD guideline.<br />
Reliability : (2) valid with restrictions<br />
Scientifically valid study, but not according to current standard or GLP<br />
Flag : Critical study for SIDS endpoint<br />
04.01.2005 (142)<br />
Species : rabbit<br />
Concentration : no data<br />
Exposure : Open<br />
Exposure time : 24 hour(s)<br />
Number of animals : 5<br />
Vehicle : no data<br />
PDII :<br />
Result : slightly irritating<br />
Classification :<br />
Method : other: see freetext TC<br />
Year : 1962<br />
GLP : no<br />
Test substance : other TS: o-toluidine, no data on purity<br />
<strong>UNEP</strong> PUBLICATIONS 149
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