o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
224<br />
System of testing : Mouse kidney C3H2K cells<br />
Test concentration : 1.0 - 100 µg<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : without<br />
Result : negative<br />
Method : other: according Yoshikura et al., 1979<br />
Year : 1981<br />
GLP : no data<br />
Test substance : other TS: see freetext TC<br />
Test condition : This study is part of a International Collaborative Program, published as:<br />
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation<br />
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981<br />
CHEMICALS:<br />
42 coded chemicals were investigated in short-term tests for<br />
cancerogenicity in different laboratories<br />
It should be suggested that only 100%-pure chemicals should be used<br />
when evaluating a test system.<br />
---In the present work the compound with code no 41 is declared as otoluidine<br />
hydrochloride, whereas in an the overall summary of this program<br />
code no. 41 is declared as o-toluidine.<br />
Reliability : (4) not assignable<br />
Method-Evaluation, unsuitable test system, unclear use: o-toluidine or otoluidine<br />
hydrochloride<br />
15.07.2004 (152) (314)<br />
Type : other: inhibition of metabolic cooperation<br />
System of testing : Chinese hamster V79 cells<br />
Test concentration : no data, see remarks<br />
Cycotoxic concentr. : no data<br />
Metabolic activation : no data<br />
Result : positive<br />
Method : other<br />
Year : 1986<br />
GLP : no data<br />
Test substance : no data<br />
Remark : inhibition of metabolic cooperation at concentration higher<br />
than 0.5 mM<br />
Reliability : (4) not assignable<br />
Method-Evaluation, insufficient documentation<br />
15.07.2004 (315)<br />
Type : other: inhibition of metabolic cooperation<br />
System of testing : Chinese hamster V79 cells<br />
Test concentration : 16, 47, 157, 470, 1570, 4700 µM<br />
Cycotoxic concentr. : 4700 µM<br />
Metabolic activation : without<br />
Result : positive<br />
Method : other<br />
Year : 1985<br />
GLP : no data<br />
Test substance : other TS: o-toluidine, no data on purity<br />
Reliability : (4) not assignable<br />
Method-Evaluation<br />
15.07.2004 (316) (317) (318) (319)<br />
Type : other: inhibition of metabolic cooperation<br />
<strong>UNEP</strong> PUBLICATIONS
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