o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
code no. 41 is declared as o-toluidine.
METABOLIC ACTIVATION:
S9 mix - liver homogenates from with Aroclor 1254 induced rats
Reliability : (4) not assignable
Method-Evaluation, no data on cytotoxicity, unclear use: o-toluidine or otoluidine
hydrochloride
15.07.2004 (152) (247)
Type : Gene mutation in Saccharomyces cerevisiae
System of testing : Saccharomyces cervisiae D4
Test concentration : 0.33, 1.0, 3.33, 10.0, 33.33, 100.0, 333.33 µg/plate
Cycotoxic concentr. : no data
Metabolic activation : with and without
Result : negative
Method : other: modification of the method described by Zimmermann (1975)
Year : 1981
GLP : no data
Test substance : other TS: see freetext TC
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
---In the present work the compound with code no 41 is declared as otoluidine
hydrochloride, whereas in the overall summary of this program
code no. 41 is declared as o-toluidine.
METABOLIC ACTIVATION:
S9 mix - liver homogenates from with Aroclor 1254 induced male Sprague
Dawley rats
Reliability : (2) valid with restrictions
Method-Evaluation, unclear use: o-toluidine or o-toluidine hydrochloride
15.07.2004 (152) (248)
Type : Gene mutation in Saccharomyces cerevisiae
System of testing : strain D6
Test concentration : up to 2000 µg/ml
Cycotoxic concentr. : no data
Metabolic activation : with and without
Result : positive
Method : other: modified according Parry and Zimmermann (1976)
Year : 1981
GLP : no data
Test substance : other TS: see freetext TC
Result : mitotic aneuploidy, the lowest positive concentration was 600 µg/ml
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
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