o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
176
Method-Evaluation, only 4 concentrations tested, unclear use: o-toluidine
or o-toluidine hydrochloride
15.07.2004 (186) (152)
Type : Ames test
System of testing : Salmonella typhimurium TA 92, TA 98, TA 100, TA 1535, TA 1537, TA
1538
Test concentration : 0.2, 2, 20, 200 and 2000 µg/plate
Cycotoxic concentr. : preliminary cytotoxicity test
Metabolic activation : with and without
Result : negative
Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975)
Year : 1981
GLP : no data
Test substance : other TS: see freetext TC
Method : The method was basically described by Ames et al. but included a period
of incubation of test compound and bacteria, or test compound, bacteria,
and S9 mix.
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
---In the present work the compound with code no 41 is declared as otoluidine
hydrochloride, whereas in an the overall summary of this program
code no. 41 is declared as o-toluidine.
METABOLIC ACTIVATION:
S9 mix - liver homogenates from with Aroclor 1254 induced male Wistar
rats
Reliability : (2) valid with restrictions
Method-Evaluation, well documented, unclear use: o-toluidine or o-toluidine
hydrochloride
15.07.2004 (187) (152)
Type : Ames test
System of testing : Salmonella typhimurium TA 98, TA 100, TA 1537
Test concentration : 100, 500, 2000, 5000 µg/plate in DMSO
Cycotoxic concentr. : 5000 µg/plate
Metabolic activation : with and without
Result : negative
Method : other: according to Ames et al., Mutat. Res. 31, 347 (1975)
Year : 1981
GLP : no data
Test substance : other TS: see freetext TC
Test condition : This study is part of a International Collaborative Program, published as:
Evaluation of Short-Term Tests for Cancerogens Progress in Mutation
Research Vol 1. Edited by Frederick J. Serres and John Ashby, 1981
CHEMICALS:
42 coded chemicals were investigated in short-term tests for
cancerogenicity in different laboratories
It should be suggested that only 100%-pure chemicals should be used
when evaluating a test system.
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