o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
238<br />
and better comparability of the data obtained with in vivo Comet<br />
experiments. These aspects include: number of doses tested, number of<br />
animals per dose, slides per animal, number of cells, sufficient DNA<br />
migration in cells of concurrent controls and minimum time of treatment of<br />
slides with alkaline buffer.<br />
18.05.2004 (300)<br />
Type : other: Drosophila reversion assay<br />
Species : Drosophila melanogaster<br />
Sex : male<br />
Strain :<br />
Route of admin. : other: oral feed of larvae<br />
Exposure period : continuous feeding<br />
Doses : 10, 25, 50, 100 mM (ca. 1.1, 2.7, 5.4, 10.7 g)<br />
Result : negative<br />
Method : other: Rasmuson et al. (1978): Mut. Res. 54, 33-38<br />
Year : 1983<br />
GLP : no data<br />
Test substance : other TS: no data on purity<br />
Test condition : Test system:<br />
newly hatched male larvae carrying the unstable white-zeste system and<br />
an excision-repair deficient gene mei-9a<br />
Reliability : (4) not assignable<br />
no validated test system<br />
02.06.2004 (344) (345)<br />
Type : other: Inhibition of Testicular DNA-Synthesis<br />
Species : mouse<br />
Sex : male<br />
Strain : no data<br />
Route of admin. : oral unspecified<br />
Exposure period :<br />
Doses : 0, 200 mg/kg b.w.<br />
Result : positive<br />
Method : other: according to Friedman and Staub, 1976, Mutation Res. 37, 67-76,<br />
see also freetext TC<br />
Year : 1977<br />
GLP : no data<br />
Test substance : other TS:o-toluidine, no data on purity<br />
Result : Incorporation of the tritiated thymidine = 75% of concurrent controls<br />
Test condition : Measurement of incorporation of [3H]thymidine into testicular DNA<br />
(expressed as cpm per µg DNA).<br />
The mean values were then tested for statistically significant deviations<br />
from the concurrent controls by simplified t-test.<br />
Method evaluation<br />
Reliability : (4) not assignable<br />
Method evaluation<br />
02.06.2004 (346)<br />
Type : other: Somatic recombination and mutation (SRM) assay<br />
Species : Drosophila melanogaster<br />
Sex : male/female<br />
Strain :<br />
Route of admin. : oral feed<br />
Exposure period : 4 days (egg-laying period)<br />
Doses : 2.0 - 8.0 mM<br />
Result : positive<br />
Method : other: Becker, H.J. (1966): Curr. Topics Develop. Biol. 1,155-171<br />
Year : 1985<br />
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