o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
248<br />
the end of study (no further details reported)<br />
- HISTOPATHOLOGY<br />
tissues examined:<br />
- skin, lungs and bronchi, trachea, bone marrow (femur),<br />
- spleen, lymph nodes (mesenteric and submandibular),<br />
- thymus, heart, salivary gland (parotid, sublingual, and<br />
- subaxillary), liver, pancreas, esophagus, stomach<br />
- (glandular and nonglandular), small ang large intestines,<br />
- kidney, urinary bladder, pituitary, adrenal, thyroid,<br />
- parathyroid, pancreatic islets, testis, prostata, mammary<br />
- gland, uterus ovary, brain (cerebrum and cerebellum), and<br />
- all tissue masses.<br />
Peripheral blood smears were also made<br />
- for all animals, whenever possible.<br />
STATISTICS:<br />
Product-limit procedure of Kaplan and Meier<br />
Method of Cox with Tarone's extension<br />
Fisher exact test<br />
Bonferoni inequality<br />
Cochran-Armitage<br />
Conclusion : In conclusion, o-toluidine hydrochloride is considered to be carcinogenic in<br />
male and female B6C3Fl mice.<br />
This is based on the increased incidences of hepatocellular neoplasms in<br />
female mice and hemangiosarcomas in high-dose males and of females<br />
exposed to the compound.<br />
Reliability : (2) valid with restrictions<br />
Flag : Critical study for SIDS endpoint<br />
24.05.2004 (159) (360) (356)<br />
Species : rat<br />
Sex : male<br />
Strain : Fischer 344<br />
Route of admin. : oral feed<br />
Exposure period : 72 weeks<br />
Frequency of treatm. : continuously<br />
Post exposure period : approx. 20 weeks<br />
Doses : 0, 4000 ppm (mean daily dose per rat - 0.062g, calculated from food<br />
consumption)<br />
Result :<br />
Control group : yes, concurrent no treatment<br />
Method : other: carcinogenicity see freetext TC<br />
Year : 1982<br />
GLP : no data<br />
Test substance : other TS: o-Toluidine hydrochloride, purified by recrystallization:<br />
m.p.: 216-218°C<br />
Result : ---mean daily food consumption/rat:<br />
15.5 g in the treatment group versus 17.9 g in controls<br />
---mean daily dose: 0.062 g 0-toluidine hydrochloride<br />
Mortality:<br />
treatment-group: no death up to month 14; month 22: 6/30 surviving rats<br />
control-group: no death up to month 12; month 22: 18/30 surviving control<br />
rat<br />
Mean Body weights:<br />
at onset: 132g of dosed rats as well as of controls<br />
after 1 year: 454 g(dosed rats) versus 400 g (control rats)<br />
after 93 weeks: 474 g (dosed rats) versus 411 g (control rats)<br />
Tumor incidences<br />
Number of rats necropsied: 30 dosed rats, 27 control rats<br />
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