o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
140
Insufficient documentation and/or Secondary literature
02.06.2004 (144)
Type : LD50
Value : = 940 mg/kg bw
Species : rat
Strain : other: Carworth-Wistar
Sex : male
Number of animals : 5
Vehicle : no data
Doses : individual doses not mentioned
Method : other: see ME and TC
Year : 1962
GLP : no
Test substance : other TS: o-toluidine, no data on purity
Method : according to Smyth et al., Am. Ind. Hyg. Ass. J. 23, 95-107 (1962),
based upon mortalities during a 14-day observation period the most
probable LD50 value and its fiducial range are estimated by the method of
Thompson (1947) using the tables of Weil (1952)
Result : LD50 = 940 mg/kg bw
confidence limits as +- 1.96 standard deviation =
670 - 1310 mg/kg
Test condition : TEST ORGANISMS:
- Animals: Carworth-Wistar male rats
- Age: 4 - 5 weeks
- Weight at study initiation: 90 - 120 g
ADMINISTRATION:
- Route: gavage
- Doses: dosages were arranged in a logarithmic series
differing by a factor of two
- Doses per time period: single dose at nonfasted animals
- Post dose observation period: 14 days
Reliability : (2) valid with restrictions
no necropsy and no histopathological examinations were performed
02.06.2004 (145)
Type : LD50
Value : = 2951 mg/kg bw
Species : rat
Strain : Osborne-Mendel
Sex : male
Number of animals : 10
Vehicle : water
Doses : see freetext TC
Method : other: single dose by stomach tube, 14-day observation period, calculation
of LD50 with the Bliss probit method
Year : 1969
GLP : no
Test substance : other TS: o-toluidine-hydrochloridepurified by reccrystalisation (no further
data on purity)
Test condition : TEST ORGANISMS:
- Animals: Osborne-Mendel male rats
- Weight at study initiation: 250 g
ADMINISTRATION:
- Route: gavage
- Doses: dosages in a series of 3 levels at 10 antilog unit
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