o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 148 Exposure : Semiocclusive Exposure time : 24 hour(s) Number of animals : 2 Vehicle : other: none PDII : Result : not irritating Classification : Method : other: see freetext TC Year : 1979 GLP : no Test substance : as prescribed by 1.1 - 1.4 Result : none of the test-ears showed a reaction on treatment Test condition : TEST ORGANISMS: Strain: New Zealand White Sex: male and female Body weight: 3 - 4 kg ADMINISTRATION: A patch with the 500 µl o-toluidine was fixed on the skin of the inner surface of the ear for 24 h. Thereafter skin was washed with water and soap or plantoil. Post exposure observation period: 7 days Evaluation for erythema, swelling, corrosivity Reliability : (2) valid with restrictions limited test description, only 2 animals Flag : Critical study for SIDS endpoint 02.06.2004 (154) Species : rabbit Concentration : undiluted Exposure : Occlusive Exposure time : 24 hour(s) Number of animals : 6 Vehicle : other: none PDII : Result : moderately irritating Classification : Method : other: Draize Test according Fed. Reg, 38, No,187, §1500.41, p. 27029 (1973/sept./ 27) see also freetext ME Year : 1979 GLP : no Test substance : other TS: o-toluidine, purity: 99.5 % Method : Six White Vienna rabbits were treated for 24 hours using occlusive conditions. Two application sites of 2.5X2.5 cm² were covered with the undiluted liquid test substance. One application site (left flank) was scarified before application. After application time the skin was washed with water. The animals were kept for 9 days and skin changes were observed on working days reading: 24, 48, 72 hours after beginning of application and 8 days after removal of the dressing Soring: OECD Draize Scores Result : Reading: Rabbit 1/2/3/4/5/6 // medium score erythema: 0=no erythema1=questionable, 2=slight, 3=moderate, 4=severe edema: 1=very slight, 2=slight, 3=moderate,4=severe s=scaling, n=necrosis soft, np=necrosis parchmentlike nl=necrosis leathery, *=extending beyond the area of exposure UNEP PUBLICATIONS
OECD SIDS o-TOLUIDINE 5. TOXICITY ID: 95-53-4 DATE: 07.01.2005 1) intact skin: erythema: 24 hrs: 2 /2 /4+n /2 /2 /2 // 2.3 48 hrs: 2 /2 /4+n /2 /1 /1 // 2.0 72 hrs: 2+s/1+s/4+np /1+s/1+s/1+s // 1.7 8d : 0+s/0+s/4+npl/0+s/0+s/0+s // 0.7 edema: 24 hrs: 2/2/2 /2/2/2 // 2.0 48 hrs: 0/0/2*/0/0/0 // 0.3 72 hrs: 0/0/2*/0/0/0 // 0.3 8d : 0/0/2*/0/0/0 // 0.3 Total recovery within the following days No mortallity occurred. There were no clinical signs of systemic toxicity from the dermal exposure. 2) scarified skin erythema 24 hrs: 2 /2 /4+n/2+n/2+n /4+n // 2.7 72 hrs: 2+s /2+s /4+n/2+n/2+n /4+n // 2.7 8d : 1+s+n/1+s+n/4+n/4+n/1+s+n/4+n // 2.6 edema 24 hrs: 2/2/2/2/2/3 // 2.2 72 hrs: 2/1/2/1/2/2 // 1.7 8d : 1/1/2/1/1/2 // 1.3 Necrotic tissue damage was observed. In summary: The treatment led to slight or moderate erythema and moderate edema in 5/6 animals up to 72 and 24 hours after start of the application. At 72 hrs after application these animals exhibited scaling which was still observed on day 8. Necrosis (soft, parchmentlike, or leathery) was observed in 1/6 animals until termination of the study. the clinical finding of necrosis was confirmed by macroscopic pathology. Source : BASF AG Conclusion : corrosive (moderate) The conclusion is based on the skin necrosis observed in 1/6 animals. If the evaluation would take only account of the 5 animals not displaying skin necrosis, the test substance would be regarded as non-irritant according to current criteria. Thus theconclusion of this test may be more stringent than one derived from a four-hour semi occluded application as required by the current OECD guideline. Reliability : (2) valid with restrictions Scientifically valid study, but not according to current standard or GLP Flag : Critical study for SIDS endpoint 04.01.2005 (142) Species : rabbit Concentration : no data Exposure : Open Exposure time : 24 hour(s) Number of animals : 5 Vehicle : no data PDII : Result : slightly irritating Classification : Method : other: see freetext TC Year : 1962 GLP : no Test substance : other TS: o-toluidine, no data on purity UNEP PUBLICATIONS 149
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OECD SIDS o-TOLUIDINE FOREWORD INTR
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OECD SIDS o-TOLUIDINE 11. Comments:
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OECD SIDS o-TOLUIDINE and transitio
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OECD SIDS o-TOLUIDINE 6 REFERENCES
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OECD SIDS o-TOLUIDINE Bringmann G,
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OECD SIDS o-TOLUIDINE Hecht SS, El-
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o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

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