o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals
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OECD SIDS o-<strong>TOLUIDINE</strong><br />
5. TOXICITY ID: <strong>95</strong>-<strong>53</strong>-4<br />
DATE: 07.01.2005<br />
Test condition : ANIMALS<br />
obtained as 4-week -old weanlings , all within 3 days of the same age<br />
housed for 2 weeks before start of the study<br />
- Number of animals: 5 per sex and dose<br />
ANIMAL MAINTENANCE<br />
- water provided ad libitum<br />
- air of the animal room at a temperature of 22-24°C, relative humidity:<br />
45-55%, room air changed 15 times per hour<br />
- fluorescence lightening : 12 hour per day cycle<br />
ADMINISTRATION / EXPOSURE<br />
- Diet: presterilized Wayne Sterilizable Lab Meal with 4%<br />
fat, provided at libitum<br />
- Doses: 0, 3100-6200-8000-10000-12500-20000-25000 and<br />
50000 ppm (approximately 0, 465-930-1200-1500-2400-3000- and 7500<br />
mg/kg bw/d), prepared fresh every 1 to 1-1/2 weeks<br />
CLINICAL OBSERVATIONS AND FREQUENCY:<br />
- Clinical signs: daily<br />
- Mortality: twice daily<br />
- Body weight: twice per week<br />
NECROPSY:<br />
at the end of study, gross examination of spleen, kidneys and liver<br />
Evaluation of the results: Ten percent depression in body weight was taken<br />
as the major criterion for the estimation of maximum tolerated dose<br />
Conclusion : Based on the data the low and high dose for a carcinogenesis bioassay<br />
were set on 1000 and 3000 ppm.<br />
Reliability : (2) valid with restrictions<br />
dose finding study for carcinogenisis bioassay<br />
24.05.2004 (159)<br />
Type : Sub-chronic<br />
Species : rat<br />
Sex : no data<br />
Strain : no data<br />
Route of admin. : oral feed<br />
Exposure period : 91 days<br />
Frequency of treatm. : continuous<br />
Post exposure period :<br />
Doses : 15 - 24 mg/animal (reduced for toxicity at 7.5 - 12 mg/animal)<br />
Control group : no data specified<br />
Method : other: see TC<br />
Year :<br />
GLP : no<br />
Test substance : other TS: no data on purity<br />
Result : 3/10 animals showed changes in the mucous membrane of the bladder<br />
with metaplasia and early epithelial proliferation<br />
Test condition : 10 rats were given a basic diet of rice flour with addition of a slice of carrot<br />
about every other day, and o-toluidine was added to the rice flour.<br />
Reliability : (4) not assignable<br />
documentation insufficient for assessment<br />
18.12.2003 (160) (161)<br />
Type :<br />
Species : rat<br />
Sex : no data<br />
Strain : no data<br />
Route of admin. : dermal<br />
<strong>UNEP</strong> PUBLICATIONS 161
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