o-TOLUIDINE CAS N°: 95-53-4 - UNEP Chemicals

OECD SIDS o-TOLUIDINE
5. TOXICITY ID: 95-53-4
DATE: 07.01.2005
Doses
Males :
Females :
Vehicle :
Route of administration : inhalation
Exposure time :
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Method :
Year : 1986
GLP : no data
Test substance : other TS: o-toluidine, no further data
Remark : 24h urine collections were obtained from healthy male smokers (n=16) and
non-smokers (n=12) who were 25-45 years old. Urine was collected at 3
days.
-- in Smokers: 6.3 µg/24 hrs o-toluidine was detected
--in Non-smokers: 4.2 µg/24 hrs o-toluidine was detected
Reliability : (4) not assignable
abstract
05.05.2004 (139) (140)
5.1.1 ACUTE ORAL TOXICITY
Type : LD50
Value : = .75 ml/kg bw
Species : rat
Strain : other: Wistar-II
Sex : male
Number of animals : 10
Vehicle : other: none
Doses : 0.600 - 0.650 - 0.700 - 0.800 - 0.900 ml/kg bw, undiluted (see also TC)
Method : other: see ME and TC
Year : 1978
GLP : no
Test substance : as prescribed by 1.1 - 1.4
Method : Calculation of the median lethal dose (LD50) according to Fink and Hund
(Arzneim. Forsch. 15, 1965, 624)
Result : MORTALITY:
Dose [ml/kg bw]:
0.60: 0/10
0.65: 1/10 4d post application
0.70: 4/10 within 3-4 days post application
0.80: 6/10 within 2-4 days post application
0.90: 10/10 within 2-5 days post application
LD50: 0.75 ml/kg bw (corresponding to 750 mg/kg bw)
CLINICAL SIGNS:
600 mg/kg: reduced general condition at day 2
650 mg/kg: reduced general condition, anesthesia
day 1 up to day 14
700 mg/kg: reduced general condition, anaesthesia,
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