m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
4. ECOTOXICITY ID: 108-39-4
DATE: 24.05.2004
4.7 BIOLOGICAL EFFECTS MONITORING
4.8 BIOTRANSFORMATION AND KINETICS
Remark : In aquarium water of 12 species of freshwater fish 48 h
after exposure to 3-15 mg/l m-cresol, cresyl sulphate
(55-64% of 14C recovered) or m-hydroxybenzoic acid (0-39 %)
were found
In bile of 11 species, cresyl glucuronide (63-74 %), cresyl
sulphate (8-20 %) and m-hydrobenzoic acid (5-12 %) were
found
Unchanged m-cresol detected in both aquarium water and bile
Test substance : m-[U-14C]cresol
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally
accepted scientific standards and described in sufficient
detail
17.10.2001 (102)
4.9 ADDITIONAL REMARKS
116
Memo : Sea urchin test
Remark : Strongylocentrotus droebachiensis (sea urchin):
static test, 5 degrees C
Determined effect endpoints: death, pathology, inhibition of
cleavage and differentiation, pigment defects
EC50 (96 h): ca. 30 mg/l
Test substance : other TS: m-cresol, purity > 98 % as determined by GC (obtained from
Merck)
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally
accepted scientific standards and described in sufficient
detail
07.05.2004 (57)
Memo : Tree neoplasms
Remark : m-cresol (1.5 % v/v) showed a toxicity rating from 3-4 (0 =
no injury, 5 = complete kill within 14 d) in tomato crown
gall tumors incited by Agrobacterium tumefaciens.
Test substance : other TS: m-cresol, no purity reported
Reliability : (3) invalid
Unsuitable test system
07.05.2004 (103)
Memo : Hela cell screening
Remark : In a rapid-cell culture assay with HeLa cells, m-cresol
(4x10-5 to 4x10-3 M, 4 h incubation) showed a
concentration-dependent inhibition of 3H labeled thymidine
incorporation into DNA
incubation 4 h
Test substance : other TS: m-cresol, no purity reported
Reliability : (3) invalid
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