m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
5.0 TOXICOKINETICS, METABOLISM AND DISTRIBUTION
In Vitro/in vivo : In vitro
Type : Absorption
Species : other: human skin
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle : Water
Route of administration : dermal
Exposure time : 250 minute(s)
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Method : other: see freetext ME
Year : 1977
GLP : no data
Test substance : other TS: p-cresol, purity: reagent grade
Method : The permeability of p-Cresol was measured across 2.5 cm2 epidermal
membranes from human abdominal skin. The membranes were supported
in a glass cell and the amount of p-Cresol passing to the receptor vessel
measured spectrophotometrically. Each test was conducted at least in
duplicate and at 25 Degree Celsius
Result : The permeability coefficient of p-Cresol was 2.92 x10 (exp)-4 cm/min and
the lag time for a 0.4%w/v solution was 16 min. The threshold
concentration for damage i.e. the aqueous concentration at which the
permeability coefficient began to increase was 8.85 %w/v.
Reliability : (2) valid with restrictions
in vitro investigation
Flag : Critical study for SIDS endpoint
06.02.2004 (121)
In Vitro/in vivo : In vivo
Type : Toxicokinetics
Species : Rabbit
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle : other: sodium hydroxycarbonate
Route of administration : gavage
Exposure time :
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
UNEP PUBLICATIONS 249