m-Cresol - ipcs inchem

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OECD SIDS m- / p-CRESOL MIXTURE 5. TOXICITY ID: 15831-10-4 DATE: 24.05.2004 Sex : male/female Strain : other: F334/N Route of admin. : oral feed Exposure period : 13 w Frequency of treatm. : continuously in feed Post exposure period : no Doses : 0, 1880, 3750, 7500, 15000, 30000 ppm (see RM) Control group : yes, concurrent no treatment NOAEL : 3750 ppm Method : other: see freetext ME Year : 1991 GLP : yes Test substance : other TS: m-/p-cresol (60%:40% mixture) Method : SIZE OF STUDY GROUP: 20 male and 20 female rats (10 of each group designated for clinical pathology studies) TIME HELD BEFORE STUDY: 12-13 days METHOD OF ANIMAL DISTRIBUTION: randomized for each sex on the basis of body weight into groups per sex DIET: NIH-07 rat ration ANIMAL ROOM ENVIRONMENT: temperature: 72° +/-3° F, humidity: 50 % +/-15 %, Fluorescent light: 12 hrs/day, room air changes: 10-12 changes/hr TYPE AND FREQUENCY OF OBSERVATION: observed twice daily, body weight taken initially, weekly, and at termination, feed consumption by cage recorded twice weekly NECROPSY AND HISTOLOGIC EXAMINATION: necropsy performed on all animals. A complete histopathologic examination was conducted on all control animals, all animals in the highest dose group with at least 60 % survivors at study termination, and all aninmals in higher dose groups inclusive of early deaths. The following organs and/or tissues were included in complete histopathological examinations, as well as any tissue masses, gross lesions, and associated regional lymph nodes: adrenals, aorta, bone (sternebrae, femur, or vertebrae, including marrow), brain, bronchi, clitoral gland, epididymis, oesophagus, heart, kidney, large intestines (caecum, colon,rectum), liver, lungs, lymph nodes (mesenteric), mammary glands, nasal cavity and turbinates, oral cavity, ovaries, pancreas, parathyroids, pharynx, pituitary, preputial gland, prostate, salivary glands, scrotal sac, seminal vesicles, skin, small intestine (duodenum, ileum, jejunum), spleen, stomach, testes, thymus, thyroid, tongue, trachea, tunica vaginalis, urinary bladder, uterus and Zymbal's glands. For lower level dose groups, all gross lesions and the following target organs were examined histopathologically: bone marrow, nasal mucosa, thyroid gland, uterus. Organ weights recorded for brain, liver, right kidney, thymus, heart, and lungs of all animals, and the right testis of all males. HAEMATOLOGIC, CLINICAL CHEMISTRY, and URINALYSIS determinations included. haematocrit, haemoglobin, red blood cell count, mean cell volume (only females), meam cell haemoglobin, mean cell haemoglobin concentration (only females), platelets, reticulocytes, white blood cell count, lymphocytes, 354 UNEP PUBLICATIONS
OECD SIDS m- / p-CRESOL MIXTURE 5. TOXICITY ID: 15831-10-4 DATE: 24.05.2004 monocytes, eosinophila, urea nitrogen, alanine aminotransferase, alkaline phosphatase, 5'-nucleotidase, sorbitoldehydrogenase, bile acids, urine aspartate aminotransferase, urine n-acetyl-ß-glucose amidase, urine volume, specific gravity reproductive toxicity evaluation as described in chapter 5.8.3. STATISTICAL METHODS: nonparametric multiple comparison test of Dunn and Shirley, Jonckheere's test, arcine transformation, multivariate analysis of variance Remark : mean compound consumption (mg/kg bw/day): males females 0 ppm 0 0 1880 ppm 123 131 3750 ppm 241 254 7500 ppm 486 509 15000 ppm 991 1024 30000 ppm 2014 2050 Result : All rats lived to the end of the study; clinical signs of toxicity: 30000 ppm: males, females, rough hair coat, urine-stained fur; females, thin appearance; 15000-3750 ppm: females, urine stained fur 15000, 30000 ppm: males, females, final body weight reduced; females, reduced weight gain; 30000 ppm: males, weight gain reduced; males, females, reduced feed consumption during the first week At study termination weights (w) were sign. increased (mainly p
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS m- / p-CRESOL MIXTURE I U
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